Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an induc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X17301388 |
| _version_ | 1818120197411700736 |
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| author | George S. Hussey Madeline C. Cramer Stephen F. Badylak |
| author_facet | George S. Hussey Madeline C. Cramer Stephen F. Badylak |
| author_sort | George S. Hussey |
| collection | DOAJ |
| description | Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach. |
| first_indexed | 2024-12-11T05:22:16Z |
| format | Article |
| id | doaj.art-5f2b4cac7b9b447ea73f989f909dd99e |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-11T05:22:16Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-5f2b4cac7b9b447ea73f989f909dd99e2022-12-22T01:19:40ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2018-01-015111310.1016/j.jcmgh.2017.09.004Extracellular Matrix Bioscaffolds for Building Gastrointestinal TissueGeorge S. Hussey0Madeline C. Cramer1Stephen F. Badylak2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaRegenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach.http://www.sciencedirect.com/science/article/pii/S2352345X17301388Extracellular MatrixBioscaffoldsRegenerative MedicineTissue EngineeringGastrointestinal Tract |
| spellingShingle | George S. Hussey Madeline C. Cramer Stephen F. Badylak Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue Cellular and Molecular Gastroenterology and Hepatology Extracellular Matrix Bioscaffolds Regenerative Medicine Tissue Engineering Gastrointestinal Tract |
| title | Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue |
| title_full | Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue |
| title_fullStr | Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue |
| title_full_unstemmed | Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue |
| title_short | Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue |
| title_sort | extracellular matrix bioscaffolds for building gastrointestinal tissue |
| topic | Extracellular Matrix Bioscaffolds Regenerative Medicine Tissue Engineering Gastrointestinal Tract |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X17301388 |
| work_keys_str_mv | AT georgeshussey extracellularmatrixbioscaffoldsforbuildinggastrointestinaltissue AT madelineccramer extracellularmatrixbioscaffoldsforbuildinggastrointestinaltissue AT stephenfbadylak extracellularmatrixbioscaffoldsforbuildinggastrointestinaltissue |