Occurrence of fatal infective endocarditis: a population-based study in Finland
Abstract Background Infective endocarditis (IE) is a serious mainly bacterial infection associated with high mortality. Epidemiology of fatal IE is however largely unknown. We studied occurrence and trends of fatal IE in a population-based setting. Methods All adults (≥18 years of age) who deceased...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-11-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4620-0 |
| _version_ | 1818554876704063488 |
|---|---|
| author | Elina Ahtela Jarmo Oksi Jussi Sipilä Päivi Rautava Ville Kytö |
| author_facet | Elina Ahtela Jarmo Oksi Jussi Sipilä Päivi Rautava Ville Kytö |
| author_sort | Elina Ahtela |
| collection | DOAJ |
| description | Abstract Background Infective endocarditis (IE) is a serious mainly bacterial infection associated with high mortality. Epidemiology of fatal IE is however largely unknown. We studied occurrence and trends of fatal IE in a population-based setting. Methods All adults (≥18 years of age) who deceased due to IE in Finland during 2004–2016 were studied. Data was collected from the nationwide, obligatory Cause of Death Registry. Background population consisted of 28,657,870 person-years and 651,556 deaths. Results Infective endocarditis contributed to death in 754 cases and was the underlying cause of death in 352 cases. The standardized incidence rate of deaths associated with IE was 1.42 (95% confidence interval (CI): 1.32–1.52) per 100,000 person-years. Incidence rate increased progressively with aging from 50 years of age. Men had a two-fold risk of acquiring fatal infective endocarditis compared to women (risk ratio (RR) 1.95; 95% CI: 1.71–2.22; P < 0.0001). On average, IE contributed to 1.16 (95% CI: 1.08–1.24) out of 1000 deaths in general adult population. The proportionate amount of deaths with IE was highest in population aged < 40 years followed by gradual decrease with aging. Incidence rate and proportion of deaths caused by IE remained stable during the study period. Conclusions Our study describes for the first time the population-based epidemiology of fatal IE in adults. Men had a two-fold risk of acquiring fatal IE compared to women. Although occurrence of fatal IE increased with aging, the proportion of deaths to which IE contributed was highest in young adult population. |
| first_indexed | 2024-12-12T09:45:50Z |
| format | Article |
| id | doaj.art-5f2b77f0aed44f088f4bb0bdbbafdb45 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T09:45:50Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-5f2b77f0aed44f088f4bb0bdbbafdb452022-12-22T00:28:25ZengBMCBMC Infectious Diseases1471-23342019-11-011911710.1186/s12879-019-4620-0Occurrence of fatal infective endocarditis: a population-based study in FinlandElina Ahtela0Jarmo Oksi1Jussi Sipilä2Päivi Rautava3Ville Kytö4Heart Center, Turku University Hospital and University of TurkuDepartment of Infectious Diseases, Turku University Hospital and University of TurkuSiun sote, North Karelia Central HospitalDepartment of Public Health, University of TurkuHeart Center, Turku University Hospital and University of TurkuAbstract Background Infective endocarditis (IE) is a serious mainly bacterial infection associated with high mortality. Epidemiology of fatal IE is however largely unknown. We studied occurrence and trends of fatal IE in a population-based setting. Methods All adults (≥18 years of age) who deceased due to IE in Finland during 2004–2016 were studied. Data was collected from the nationwide, obligatory Cause of Death Registry. Background population consisted of 28,657,870 person-years and 651,556 deaths. Results Infective endocarditis contributed to death in 754 cases and was the underlying cause of death in 352 cases. The standardized incidence rate of deaths associated with IE was 1.42 (95% confidence interval (CI): 1.32–1.52) per 100,000 person-years. Incidence rate increased progressively with aging from 50 years of age. Men had a two-fold risk of acquiring fatal infective endocarditis compared to women (risk ratio (RR) 1.95; 95% CI: 1.71–2.22; P < 0.0001). On average, IE contributed to 1.16 (95% CI: 1.08–1.24) out of 1000 deaths in general adult population. The proportionate amount of deaths with IE was highest in population aged < 40 years followed by gradual decrease with aging. Incidence rate and proportion of deaths caused by IE remained stable during the study period. Conclusions Our study describes for the first time the population-based epidemiology of fatal IE in adults. Men had a two-fold risk of acquiring fatal IE compared to women. Although occurrence of fatal IE increased with aging, the proportion of deaths to which IE contributed was highest in young adult population.http://link.springer.com/article/10.1186/s12879-019-4620-0Cause of deathEpidemiologyIncidence rateInfective endocarditis |
| spellingShingle | Elina Ahtela Jarmo Oksi Jussi Sipilä Päivi Rautava Ville Kytö Occurrence of fatal infective endocarditis: a population-based study in Finland BMC Infectious Diseases Cause of death Epidemiology Incidence rate Infective endocarditis |
| title | Occurrence of fatal infective endocarditis: a population-based study in Finland |
| title_full | Occurrence of fatal infective endocarditis: a population-based study in Finland |
| title_fullStr | Occurrence of fatal infective endocarditis: a population-based study in Finland |
| title_full_unstemmed | Occurrence of fatal infective endocarditis: a population-based study in Finland |
| title_short | Occurrence of fatal infective endocarditis: a population-based study in Finland |
| title_sort | occurrence of fatal infective endocarditis a population based study in finland |
| topic | Cause of death Epidemiology Incidence rate Infective endocarditis |
| url | http://link.springer.com/article/10.1186/s12879-019-4620-0 |
| work_keys_str_mv | AT elinaahtela occurrenceoffatalinfectiveendocarditisapopulationbasedstudyinfinland AT jarmooksi occurrenceoffatalinfectiveendocarditisapopulationbasedstudyinfinland AT jussisipila occurrenceoffatalinfectiveendocarditisapopulationbasedstudyinfinland AT paivirautava occurrenceoffatalinfectiveendocarditisapopulationbasedstudyinfinland AT villekyto occurrenceoffatalinfectiveendocarditisapopulationbasedstudyinfinland |