Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3000 |
| _version_ | 1797461350612467712 |
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| author | Barbara Vuic Tina Milos Lucija Tudor Marcela Konjevod Matea Nikolac Perkovic Maja Jazvinscak Jembrek Gordana Nedic Erjavec Dubravka Svob Strac |
| author_facet | Barbara Vuic Tina Milos Lucija Tudor Marcela Konjevod Matea Nikolac Perkovic Maja Jazvinscak Jembrek Gordana Nedic Erjavec Dubravka Svob Strac |
| author_sort | Barbara Vuic |
| collection | DOAJ |
| description | Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems and subsequently lead to chronic neuroinflammation that drives the onset and progression of neurodegenerative diseases. Since there is still no effective disease-modifying treatment, new therapeutic targets for neurodegenerative proteinopathies have been sought. The endocannabinoid system, and in particular the cannabinoid CB2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. Several studies have shown promising effects of CB2 receptor activation on reducing protein aggregation-based pathology as well as on attenuating inflammation and several dementia-related symptoms. In this review, we discuss the available data on the role of CB2 receptors in neuroinflammation and the potential benefits and limitations of specific agonists of these receptors in the therapy of neurodegenerative proteinopathies. |
| first_indexed | 2024-03-09T17:18:11Z |
| format | Article |
| id | doaj.art-5f2d4c112fbf4ad399cb6afefdde0ed0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5f2d4c112fbf4ad399cb6afefdde0ed02023-11-24T13:24:58ZengMDPI AGBiomedicines2227-90592022-11-011012300010.3390/biomedicines10123000Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic PotentialBarbara Vuic0Tina Milos1Lucija Tudor2Marcela Konjevod3Matea Nikolac Perkovic4Maja Jazvinscak Jembrek5Gordana Nedic Erjavec6Dubravka Svob Strac7Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10 000 Zagreb, CroatiaSome of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems and subsequently lead to chronic neuroinflammation that drives the onset and progression of neurodegenerative diseases. Since there is still no effective disease-modifying treatment, new therapeutic targets for neurodegenerative proteinopathies have been sought. The endocannabinoid system, and in particular the cannabinoid CB2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. Several studies have shown promising effects of CB2 receptor activation on reducing protein aggregation-based pathology as well as on attenuating inflammation and several dementia-related symptoms. In this review, we discuss the available data on the role of CB2 receptors in neuroinflammation and the potential benefits and limitations of specific agonists of these receptors in the therapy of neurodegenerative proteinopathies.https://www.mdpi.com/2227-9059/10/12/3000neurodegenerative diseasesproteinopathiesendocannabinoid systemcannabinoid CB2 receptorsneuroinflammationtherapy |
| spellingShingle | Barbara Vuic Tina Milos Lucija Tudor Marcela Konjevod Matea Nikolac Perkovic Maja Jazvinscak Jembrek Gordana Nedic Erjavec Dubravka Svob Strac Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential Biomedicines neurodegenerative diseases proteinopathies endocannabinoid system cannabinoid CB2 receptors neuroinflammation therapy |
| title | Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential |
| title_full | Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential |
| title_fullStr | Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential |
| title_full_unstemmed | Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential |
| title_short | Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential |
| title_sort | cannabinoid cb2 receptors in neurodegenerative proteinopathies new insights and therapeutic potential |
| topic | neurodegenerative diseases proteinopathies endocannabinoid system cannabinoid CB2 receptors neuroinflammation therapy |
| url | https://www.mdpi.com/2227-9059/10/12/3000 |
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