Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction
Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013. Recent years have seen the Biginelli reaction stepping further from sim...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/22/7886 |
| _version_ | 1797464419246014464 |
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| author | Zeyu Ma Bo Wang Lei Tao |
| author_facet | Zeyu Ma Bo Wang Lei Tao |
| author_sort | Zeyu Ma |
| collection | DOAJ |
| description | Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013. Recent years have seen the Biginelli reaction stepping further from simple coupling tools; for example, the functions of the Biginelli product 3,4-dihydropyrimidin-2(1H)-(thi)ones (DHPM(T)) have been gradually exploited to develop new functional polymers. In this mini-review, we mainly summarize the recent progress of using the Biginelli reaction to identify polymers for biomedical applications. These polymers have been documented as antioxidants, anticancer agents, and bio-imaging probes. Moreover, we also provide a brief introduction to some emerging applications of the Biginelli reaction in materials and polymer science. Finally, we present our perspectives for the further development of the Biginelli reaction in polymer chemistry. |
| first_indexed | 2024-03-09T18:06:53Z |
| format | Article |
| id | doaj.art-5f304204fb9740e7b5ad730dbce9aa61 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:06:53Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5f304204fb9740e7b5ad730dbce9aa612023-11-24T09:22:49ZengMDPI AGMolecules1420-30492022-11-012722788610.3390/molecules27227886Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli ReactionZeyu Ma0Bo Wang1Lei Tao2The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, ChinaThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, ChinaThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, ChinaMulticomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013. Recent years have seen the Biginelli reaction stepping further from simple coupling tools; for example, the functions of the Biginelli product 3,4-dihydropyrimidin-2(1H)-(thi)ones (DHPM(T)) have been gradually exploited to develop new functional polymers. In this mini-review, we mainly summarize the recent progress of using the Biginelli reaction to identify polymers for biomedical applications. These polymers have been documented as antioxidants, anticancer agents, and bio-imaging probes. Moreover, we also provide a brief introduction to some emerging applications of the Biginelli reaction in materials and polymer science. Finally, we present our perspectives for the further development of the Biginelli reaction in polymer chemistry.https://www.mdpi.com/1420-3049/27/22/7886the Biginelli reactionfunctional polymerbioactive polymer |
| spellingShingle | Zeyu Ma Bo Wang Lei Tao Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction Molecules the Biginelli reaction functional polymer bioactive polymer |
| title | Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction |
| title_full | Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction |
| title_fullStr | Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction |
| title_full_unstemmed | Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction |
| title_short | Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction |
| title_sort | stepping further from coupling tools development of functional polymers via the biginelli reaction |
| topic | the Biginelli reaction functional polymer bioactive polymer |
| url | https://www.mdpi.com/1420-3049/27/22/7886 |
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