Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis
BackgroundIn the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone to develop psychosis. Although the transition rate to psychosis in individuals at UHR is 10% to 30% within several years, some individuals at UHR present with poor pr...
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00770/full |
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| author | Mao Fujioka Kenji Kirihara Daisuke Koshiyama Daisuke Koshiyama Mariko Tada Mariko Tada Tatsuya Nagai Tatsuya Nagai Kaori Usui Susumu Morita Shintaro Kawakami Kentaro Morita Yoshihiro Satomura Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Motomu Suga Motomu Suga Tsuyoshi Araki Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai |
| author_facet | Mao Fujioka Kenji Kirihara Daisuke Koshiyama Daisuke Koshiyama Mariko Tada Mariko Tada Tatsuya Nagai Tatsuya Nagai Kaori Usui Susumu Morita Shintaro Kawakami Kentaro Morita Yoshihiro Satomura Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Motomu Suga Motomu Suga Tsuyoshi Araki Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai |
| author_sort | Mao Fujioka |
| collection | DOAJ |
| description | BackgroundIn the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone to develop psychosis. Although the transition rate to psychosis in individuals at UHR is 10% to 30% within several years, some individuals at UHR present with poor prognoses even without transition occurring. Therefore, it is important to identify biomarkers for predicting the prognosis of individuals at UHR, regardless of transition. We investigated whether mismatch negativity (MMN) in response to both duration deviant stimuli (dMMN) and frequency deviant stimuli (fMMN) could predict prognosis, including remission and neurocognitive function in individuals at UHR.Materials and MethodsIndividuals at UHR (n = 24) and healthy controls (HC; n = 18) participated in this study. In an auditory oddball paradigm, both dMMN and fMMN were measured at baseline. Remission and neurocognitive function after > 180 days were examined in the UHR group. Remission from UHR was defined as functional and symptomatic improvement using the Global Assessment of Functioning (GAF) score and Scale of Prodromal Symptoms (SOPS) positive subscales. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia (BACS). We examined differences in MMN amplitude at baseline between those who achieved remission (remitters) and those who did not (non-remitters). Multiple regression analyses were performed to identify predictors for functioning, positive symptoms, and neurocognitive function.ResultsCompared with the HC group, the UHR group had a significantly attenuated dMMN amplitude (p = 0.003). In the UHR group, GAF scores significantly improved during the follow-up period (mean value 47.1 to 55.5, p = 0.004). The dMMN amplitude at baseline was significantly larger in the remitter (n = 6) than in the non-remitter group (n = 18) (p = 0.039). The total SOPS positive subscale scores and fMMN amplitude at baseline could predict BACS attention subscore at the follow-up point (SOPS positive subscales, p = 0.030; fMMN, p = 0.041).ConclusionOur findings indicate that dMMN and fMMN predicted remission and neurocognitive function, respectively, in individuals at UHR, which suggests that there are both promising biomarker candidates for predicting prognosis in individuals at UHR. |
| first_indexed | 2024-04-12T03:01:45Z |
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| language | English |
| last_indexed | 2024-04-12T03:01:45Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-5f3119309b6d4f1e88ce9e854206c4392022-12-22T03:50:39ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-08-011110.3389/fpsyt.2020.00770543857Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for PsychosisMao Fujioka0Kenji Kirihara1Daisuke Koshiyama2Daisuke Koshiyama3Mariko Tada4Mariko Tada5Tatsuya Nagai6Tatsuya Nagai7Kaori Usui8Susumu Morita9Shintaro Kawakami10Kentaro Morita11Yoshihiro Satomura12Shinsuke Koike13Shinsuke Koike14Shinsuke Koike15Shinsuke Koike16Shinsuke Koike17Motomu Suga18Motomu Suga19Tsuyoshi Araki20Kiyoto Kasai21Kiyoto Kasai22Kiyoto Kasai23Kiyoto Kasai24Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanThe International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Psychiatry, Kawamuro Memorial Hospital, Joetsu, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Rehabilitation, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanThe International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, JapanUniversity of Tokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM), The University of Tokyo, Tokyo, JapanCenter for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, JapanUTokyo Center for Integrative Science of Human Behaviour (CiSHuB), The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanGraduate School of Clinical Psychology, Teikyo Heisei University, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanThe International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, JapanUniversity of Tokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM), The University of Tokyo, Tokyo, JapanUTokyo Center for Integrative Science of Human Behaviour (CiSHuB), The University of Tokyo, Tokyo, JapanBackgroundIn the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone to develop psychosis. Although the transition rate to psychosis in individuals at UHR is 10% to 30% within several years, some individuals at UHR present with poor prognoses even without transition occurring. Therefore, it is important to identify biomarkers for predicting the prognosis of individuals at UHR, regardless of transition. We investigated whether mismatch negativity (MMN) in response to both duration deviant stimuli (dMMN) and frequency deviant stimuli (fMMN) could predict prognosis, including remission and neurocognitive function in individuals at UHR.Materials and MethodsIndividuals at UHR (n = 24) and healthy controls (HC; n = 18) participated in this study. In an auditory oddball paradigm, both dMMN and fMMN were measured at baseline. Remission and neurocognitive function after > 180 days were examined in the UHR group. Remission from UHR was defined as functional and symptomatic improvement using the Global Assessment of Functioning (GAF) score and Scale of Prodromal Symptoms (SOPS) positive subscales. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia (BACS). We examined differences in MMN amplitude at baseline between those who achieved remission (remitters) and those who did not (non-remitters). Multiple regression analyses were performed to identify predictors for functioning, positive symptoms, and neurocognitive function.ResultsCompared with the HC group, the UHR group had a significantly attenuated dMMN amplitude (p = 0.003). In the UHR group, GAF scores significantly improved during the follow-up period (mean value 47.1 to 55.5, p = 0.004). The dMMN amplitude at baseline was significantly larger in the remitter (n = 6) than in the non-remitter group (n = 18) (p = 0.039). The total SOPS positive subscale scores and fMMN amplitude at baseline could predict BACS attention subscore at the follow-up point (SOPS positive subscales, p = 0.030; fMMN, p = 0.041).ConclusionOur findings indicate that dMMN and fMMN predicted remission and neurocognitive function, respectively, in individuals at UHR, which suggests that there are both promising biomarker candidates for predicting prognosis in individuals at UHR.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00770/fullmismatch negativityultra-high risk for psychosislongitudinal studyremissionneurocognitive function |
| spellingShingle | Mao Fujioka Kenji Kirihara Daisuke Koshiyama Daisuke Koshiyama Mariko Tada Mariko Tada Tatsuya Nagai Tatsuya Nagai Kaori Usui Susumu Morita Shintaro Kawakami Kentaro Morita Yoshihiro Satomura Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Shinsuke Koike Motomu Suga Motomu Suga Tsuyoshi Araki Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai Kiyoto Kasai Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis Frontiers in Psychiatry mismatch negativity ultra-high risk for psychosis longitudinal study remission neurocognitive function |
| title | Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis |
| title_full | Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis |
| title_fullStr | Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis |
| title_full_unstemmed | Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis |
| title_short | Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis |
| title_sort | mismatch negativity predicts remission and neurocognitive function in individuals at ultra high risk for psychosis |
| topic | mismatch negativity ultra-high risk for psychosis longitudinal study remission neurocognitive function |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00770/full |
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