Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study
Background Although lifestyle-based treatment approaches are recommended as important aspects of depression care, the quantitative influence of aggregated healthy lifestyles on depression recurrence and mortality remains unknown.Objective To investigate the association between healthy lifestyle and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Mental Health |
| Online Access: | https://ebmh.bmj.com/content/27/1/e300915.full |
| _version_ | 1827153823696683008 |
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| author | Yu-Tao Xiang Xiaohe Wang Zhi Cao Chenjie Xu Jiahao Min |
| author_facet | Yu-Tao Xiang Xiaohe Wang Zhi Cao Chenjie Xu Jiahao Min |
| author_sort | Yu-Tao Xiang |
| collection | DOAJ |
| description | Background Although lifestyle-based treatment approaches are recommended as important aspects of depression care, the quantitative influence of aggregated healthy lifestyles on depression recurrence and mortality remains unknown.Objective To investigate the association between healthy lifestyle and the risks of first-time hospitalisation for recurrent depression and mortality.Methods 26 164 adults with depression (mean (SD) age, 56.0 (7.9) years) were included from UK Biobank between 2006 and 2010 and followed up until 2022. Depression was defined as a physician’s diagnosis in hospital admissions or the use of prescribed antidepressant medication. A weighted healthy lifestyle score (HLS) was calculated based on smoking, alcohol consumption, diet, sleep pattern, physical activity, social health, employment status and greenspace interaction.Findings Over a 13.3-year follow-up, 9740 cases of first-time hospitalisation due to depression recurrence and 1527 deaths were documented. Compared with the lowest HLS tertile, the highest tertile was associated with a 27% lower risk (HR=0.73, 95% CI 0.69 to 0.77) of first-time hospitalisation for depression recurrence and a 22% (HR=0.78, 95% CI 0.68 to 0.91) lower risk of mortality among adults with depression. Lower risks of first-time hospitalisation for depression recurrence were observed among those who smoked less, drank more alcohol, followed healthier diets and sleep patterns, spent more time employed in current job or had greater exposure to greenspace.Conclusion and implications Greater adherence to healthy lifestyle was associated with a lower risk of hospitalisation and mortality among adults with pre-existing depression. Incorporating behaviour modification as an essential part of clinical practice for depressed patients could complement medication-based therapies. |
| first_indexed | 2024-04-24T12:01:51Z |
| format | Article |
| id | doaj.art-5f31b06a969b4c658382c32228c93f07 |
| institution | Directory Open Access Journal |
| issn | 2755-9734 |
| language | English |
| last_indexed | 2025-03-20T22:27:53Z |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Mental Health |
| spelling | doaj.art-5f31b06a969b4c658382c32228c93f072024-08-08T07:30:11ZengBMJ Publishing GroupBMJ Mental Health2755-97342024-05-0127110.1136/bmjment-2023-300915Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort studyYu-Tao Xiang0Xiaohe Wang1Zhi Cao2Chenjie Xu3Jiahao Min43 University of Macau, Taipa, Macau, China1 Hangzhou Normal University, Hangzhou, Zhejiang, ChinaSchool of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Public Health, Hangzhou Normal University, Hangzhou, People`s Republic of ChinaSchool of Public Health, Hangzhou Normal University, Hangzhou, People`s Republic of ChinaBackground Although lifestyle-based treatment approaches are recommended as important aspects of depression care, the quantitative influence of aggregated healthy lifestyles on depression recurrence and mortality remains unknown.Objective To investigate the association between healthy lifestyle and the risks of first-time hospitalisation for recurrent depression and mortality.Methods 26 164 adults with depression (mean (SD) age, 56.0 (7.9) years) were included from UK Biobank between 2006 and 2010 and followed up until 2022. Depression was defined as a physician’s diagnosis in hospital admissions or the use of prescribed antidepressant medication. A weighted healthy lifestyle score (HLS) was calculated based on smoking, alcohol consumption, diet, sleep pattern, physical activity, social health, employment status and greenspace interaction.Findings Over a 13.3-year follow-up, 9740 cases of first-time hospitalisation due to depression recurrence and 1527 deaths were documented. Compared with the lowest HLS tertile, the highest tertile was associated with a 27% lower risk (HR=0.73, 95% CI 0.69 to 0.77) of first-time hospitalisation for depression recurrence and a 22% (HR=0.78, 95% CI 0.68 to 0.91) lower risk of mortality among adults with depression. Lower risks of first-time hospitalisation for depression recurrence were observed among those who smoked less, drank more alcohol, followed healthier diets and sleep patterns, spent more time employed in current job or had greater exposure to greenspace.Conclusion and implications Greater adherence to healthy lifestyle was associated with a lower risk of hospitalisation and mortality among adults with pre-existing depression. Incorporating behaviour modification as an essential part of clinical practice for depressed patients could complement medication-based therapies.https://ebmh.bmj.com/content/27/1/e300915.full |
| spellingShingle | Yu-Tao Xiang Xiaohe Wang Zhi Cao Chenjie Xu Jiahao Min Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study BMJ Mental Health |
| title | Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study |
| title_full | Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study |
| title_fullStr | Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study |
| title_full_unstemmed | Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study |
| title_short | Healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre-existing depression: a prospective cohort study |
| title_sort | healthy lifestyle and the risk of depression recurrence requiring hospitalisation and mortality among adults with pre existing depression a prospective cohort study |
| url | https://ebmh.bmj.com/content/27/1/e300915.full |
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