Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI
Summary: Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of cortical layers relies on the hemodynamic response and is biased toward large veins on the cortical surface. Functional changes in the cerebral metabolic rate of oxygen (ΔCMRO2) may reflect neural cortica...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723013530 |
| _version_ | 1797448051238895616 |
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| author | Yvette Bohraus Hellmut Merkle Nikos K. Logothetis Jozien Goense |
| author_facet | Yvette Bohraus Hellmut Merkle Nikos K. Logothetis Jozien Goense |
| author_sort | Yvette Bohraus |
| collection | DOAJ |
| description | Summary: Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of cortical layers relies on the hemodynamic response and is biased toward large veins on the cortical surface. Functional changes in the cerebral metabolic rate of oxygen (ΔCMRO2) may reflect neural cortical function better than BOLD fMRI, but it is unknown whether the calibrated BOLD model for functional CMRO2 measurement remains valid at high resolution. Here, we measure laminar ΔCMRO2 elicited by visual stimulation in macaque primary visual cortex (V1) and find that ΔCMRO2 peaks in the middle of the cortex, in agreement with autoradiographic measures of metabolism. ΔCMRO2 values in gray matter are similar as found previously. Reductions in CMRO2 are associated with veins at the cortical surface, suggesting that techniques for vein removal may improve the accuracy of the model at very high resolution. However, our results show feasibility of laminar ΔCMRO2 measurement, providing a physiologically meaningful metric of laminar functional metabolism. |
| first_indexed | 2024-03-09T14:05:49Z |
| format | Article |
| id | doaj.art-5f34b441141d4984b87e17043a4e253a |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T14:05:49Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-5f34b441141d4984b87e17043a4e253a2023-11-30T05:06:51ZengElsevierCell Reports2211-12472023-11-014211113341Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRIYvette Bohraus0Hellmut Merkle1Nikos K. Logothetis2Jozien Goense3Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72076 Tübingen, GermanyNIH/NINDS, Bethesda, MD 20824, USADepartment of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany; Department of Physiology of Cognitive Processes, International Center for Primate Brain Research, Songjiang District, Shanghai 201602, China; Centre for Imaging Sciences, University of Manchester, Manchester M13 9PT, UKDepartment of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA; Department of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL 61820, USA; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA; Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA; Corresponding authorSummary: Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of cortical layers relies on the hemodynamic response and is biased toward large veins on the cortical surface. Functional changes in the cerebral metabolic rate of oxygen (ΔCMRO2) may reflect neural cortical function better than BOLD fMRI, but it is unknown whether the calibrated BOLD model for functional CMRO2 measurement remains valid at high resolution. Here, we measure laminar ΔCMRO2 elicited by visual stimulation in macaque primary visual cortex (V1) and find that ΔCMRO2 peaks in the middle of the cortex, in agreement with autoradiographic measures of metabolism. ΔCMRO2 values in gray matter are similar as found previously. Reductions in CMRO2 are associated with veins at the cortical surface, suggesting that techniques for vein removal may improve the accuracy of the model at very high resolution. However, our results show feasibility of laminar ΔCMRO2 measurement, providing a physiologically meaningful metric of laminar functional metabolism.http://www.sciencedirect.com/science/article/pii/S2211124723013530CP: NeuroscienceCP: Metabolism |
| spellingShingle | Yvette Bohraus Hellmut Merkle Nikos K. Logothetis Jozien Goense Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI Cell Reports CP: Neuroscience CP: Metabolism |
| title | Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI |
| title_full | Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI |
| title_fullStr | Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI |
| title_full_unstemmed | Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI |
| title_short | Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI |
| title_sort | laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fmri |
| topic | CP: Neuroscience CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723013530 |
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