Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children
Objectives: To assess (a) the impact of daily preventive zinc tablets (7 mg; PZ), zinc-containing multiple micronutrient powder (10 mg zinc, and 13 other micronutrients; MNP) or placebo, delivered for 9 months, on Insulin-like Growth Factor 1 (IGF1) and IGF Binding Protein 3 (IGFBP3) among Laotian c...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2072-6643/15/11/2590 |
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| author | Maxwell A. Barffour Robin M. Bernstein Guy-Marino Hinnouho K. Ryan Wessells Charles D. Arnold Sengchanh Kounnavong Sonja Y. Hess |
| author_facet | Maxwell A. Barffour Robin M. Bernstein Guy-Marino Hinnouho K. Ryan Wessells Charles D. Arnold Sengchanh Kounnavong Sonja Y. Hess |
| author_sort | Maxwell A. Barffour |
| collection | DOAJ |
| description | Objectives: To assess (a) the impact of daily preventive zinc tablets (7 mg; PZ), zinc-containing multiple micronutrient powder (10 mg zinc, and 13 other micronutrients; MNP) or placebo, delivered for 9 months, on Insulin-like Growth Factor 1 (IGF1) and IGF Binding Protein 3 (IGFBP3) among Laotian children 6–23 months, and (b) whether the effects of PZ and MNP on length-for-age z-scores (LAZ) and weight-for-age z-scores (WAZ) are modified by baseline IGF1 and IGFBP3. Design: A double-blind, placebo-controlled trial (N = 419). Methods: Plasma IGF1 and IGFBP3 concentrations at baseline and 36 weeks were analyzed by automated chemiluminescent assay. Anthropometry was assessed at baseline, at 18 and 36 weeks. Intervention effects were estimated using ANCOVA. Results: At 36 weeks, geometric mean IGF1 (~39.0–39.2 ng/mL; <i>p</i> = 0.99) and IGFBP3 (2038–2076 ng/mL; <i>p</i> = 0.83) did not differ by group. At 18 weeks (but not at 36 weeks), LAZ in the PZ group (−1.45) was higher than the MNP (−1.70) and control (−1.55) groups (<i>p</i> = 0.01) among children in the highest baseline IGF1 tertile (<i>p</i> for interaction = 0.006). At 36 weeks (but not at 18 weeks), WAZ in the PZ group (−1.55) was significantly higher than the MNP (−1.75) and control (−1.65) groups (<i>p</i> = 0.03), among children in the lowest baseline IGFBP3 tertile (<i>p</i> for interactions = 0.06). Conclusions: Although IGF1 and IGFBP3 did not respond to PZ and MNP, baseline IGF1 and IGFBP3 significantly modified the impact of PZ on linear and ponderal growth, suggesting that IGF1 bioavailability may drive catch-up growth in zinc-supplemented children |
| first_indexed | 2024-03-11T02:59:33Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T02:59:33Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-5f359f7c2b4048dd945c49013f893ffd2023-11-18T08:22:10ZengMDPI AGNutrients2072-66432023-05-011511259010.3390/nu15112590Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian ChildrenMaxwell A. Barffour0Robin M. Bernstein1Guy-Marino Hinnouho2K. Ryan Wessells3Charles D. Arnold4Sengchanh Kounnavong5Sonja Y. Hess6Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA 95616, USADepartment of Anthropology, University of Colorado, Boulder, CO 80309, USADepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA 95616, USADepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA 95616, USADepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA 95616, USALao Tropical and Public Health Institute, Ban Kaognot, Sisattanack District, Vientiane 01030, LaosDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA 95616, USAObjectives: To assess (a) the impact of daily preventive zinc tablets (7 mg; PZ), zinc-containing multiple micronutrient powder (10 mg zinc, and 13 other micronutrients; MNP) or placebo, delivered for 9 months, on Insulin-like Growth Factor 1 (IGF1) and IGF Binding Protein 3 (IGFBP3) among Laotian children 6–23 months, and (b) whether the effects of PZ and MNP on length-for-age z-scores (LAZ) and weight-for-age z-scores (WAZ) are modified by baseline IGF1 and IGFBP3. Design: A double-blind, placebo-controlled trial (N = 419). Methods: Plasma IGF1 and IGFBP3 concentrations at baseline and 36 weeks were analyzed by automated chemiluminescent assay. Anthropometry was assessed at baseline, at 18 and 36 weeks. Intervention effects were estimated using ANCOVA. Results: At 36 weeks, geometric mean IGF1 (~39.0–39.2 ng/mL; <i>p</i> = 0.99) and IGFBP3 (2038–2076 ng/mL; <i>p</i> = 0.83) did not differ by group. At 18 weeks (but not at 36 weeks), LAZ in the PZ group (−1.45) was higher than the MNP (−1.70) and control (−1.55) groups (<i>p</i> = 0.01) among children in the highest baseline IGF1 tertile (<i>p</i> for interaction = 0.006). At 36 weeks (but not at 18 weeks), WAZ in the PZ group (−1.55) was significantly higher than the MNP (−1.75) and control (−1.65) groups (<i>p</i> = 0.03), among children in the lowest baseline IGFBP3 tertile (<i>p</i> for interactions = 0.06). Conclusions: Although IGF1 and IGFBP3 did not respond to PZ and MNP, baseline IGF1 and IGFBP3 significantly modified the impact of PZ on linear and ponderal growth, suggesting that IGF1 bioavailability may drive catch-up growth in zinc-supplemented childrenhttps://www.mdpi.com/2072-6643/15/11/2590IGF1IGFBP3zinc supplementationmultiple micronutrient powderphysical growth |
| spellingShingle | Maxwell A. Barffour Robin M. Bernstein Guy-Marino Hinnouho K. Ryan Wessells Charles D. Arnold Sengchanh Kounnavong Sonja Y. Hess Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children Nutrients IGF1 IGFBP3 zinc supplementation multiple micronutrient powder physical growth |
| title | Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children |
| title_full | Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children |
| title_fullStr | Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children |
| title_full_unstemmed | Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children |
| title_short | Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children |
| title_sort | insulin like growth factor 1 igf1 igf binding protein 3 igfbp3 and growth response to daily zinc supplementation a randomized trial in rural laotian children |
| topic | IGF1 IGFBP3 zinc supplementation multiple micronutrient powder physical growth |
| url | https://www.mdpi.com/2072-6643/15/11/2590 |
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