Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan

Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan

To explain the insurmountable/long-lasting binding of biphenyltetrazole-containing AT1-receptor antagonists such as candesartan, to the human angiotensin II type 1-receptor, a model is proposed in which the basic amino acids Lys199 and Arg 167 of the receptor interact respectively with the carboxyla...

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Bibliographic Details
Main Authors: Georges Vauquelin, Frederik LP Fierens, Zsuzsanna Gáborik, Tam Le Minh, Jean-Paul De Backer, László Hunyady, Patrick ML Vanderheyden
Format: Article
Language:English
Published: SAGE Publications 2001-03-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/14703203010020010501

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