In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

Abstract Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens in organoids could link genetic perturbations with parallel transcript...

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Bibliographic Details
Main Authors:	Junbo Liang, Jinsong Wei, Jun Cao, Jun Qian, Ran Gao, Xiaoyu Li, Dingding Wang, Yani Gu, Lei Dong, Jia Yu, Bing Zhao, Xiaoyue Wang
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Genome Biology
Subjects:	Hepatocyte differentiation and maturation Organoid Single-cell CRISPR screen Regulon
Online Access:	https://doi.org/10.1186/s13059-023-03084-8

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