A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity
Chemical and biological methods are available for synthesizing manganese dioxide nanoparticles, with the characteristic electrochemical features tunable through natural product extract. MnO2 nanoparticles reduce the prevalence of organism resistance to drugs. Manganese dioxide nanoparticles are effe...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-01-01
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| Series: | Nanomedicine Journal |
| Subjects: | |
| Online Access: | https://nmj.mums.ac.ir/article_21163_c6266214ae9f3da89c15076cc62ead59.pdf |
| _version_ | 1797848904920727552 |
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| author | Jino Affrald R Nandhini M Shoba Narayan |
| author_facet | Jino Affrald R Nandhini M Shoba Narayan |
| author_sort | Jino Affrald R |
| collection | DOAJ |
| description | Chemical and biological methods are available for synthesizing manganese dioxide nanoparticles, with the characteristic electrochemical features tunable through natural product extract. MnO2 nanoparticles reduce the prevalence of organism resistance to drugs. Manganese dioxide nanoparticles are effective against various bacteria, including Staphylococcus aureus and E. coli. Manganese dioxide nanoparticles can potentially be used in the treatment of osteoarthritis and the preservation of cartilage. They are also promising ROS scavengers and may be used to fabricate antioxidant polymer microreactors. In cancer treatment, the MnO2 nanoparticles inhibit ATP production by cancer cells. In magnetic resonance imaging, the nanoparticles improve the signal-to-noise ratio and selectivity. Based on this background information, MnO2 nanoparticles today find use in photodynamic, chemodynamic, and immune therapy and diagnostics, where the oxygen produced by MnO2 nanoparticles is said to improve the therapeutic efficiency. Hybrid nanoparticles of gold nanorods and MnO2 nanoparticles enhance the performance in hormone-, pH-, and NIR- responsiveness. Other applications include glucose oxidase activity, photothermal conversion, and enhanced antitumor immunity. On the other hand, the nanoparticles can cause spermatogenesis failure, oxidative stress, active oxygen, and sperm motility reduction. As surface functionalization can improve the overall functional properties of the nanoparticles, polymer coating on MnO2 nanoparticles brings about new and improved properties. For instance, the layer of biopolymers such as chitosan enhances the magnetic resonance images’ quality and opens up the potential for attaching drugs and targeting moieties. |
| first_indexed | 2024-04-09T18:36:15Z |
| format | Article |
| id | doaj.art-5f3ed9cdeac94c1995819ce0912a7db9 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-04-09T18:36:15Z |
| publishDate | 2023-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-5f3ed9cdeac94c1995819ce0912a7db92023-04-11T10:11:23ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042023-01-0110111510.22038/nmj.2022.66131.169421163A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicityJino Affrald R0Nandhini M1Shoba Narayan2Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chengalpattu District, Chennai, Tamil Nadu, 603103, IndiaFaculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chengalpattu District, Chennai, Tamil Nadu, 603103, IndiaFaculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chengalpattu District, Chennai, Tamil Nadu, 603103, IndiaChemical and biological methods are available for synthesizing manganese dioxide nanoparticles, with the characteristic electrochemical features tunable through natural product extract. MnO2 nanoparticles reduce the prevalence of organism resistance to drugs. Manganese dioxide nanoparticles are effective against various bacteria, including Staphylococcus aureus and E. coli. Manganese dioxide nanoparticles can potentially be used in the treatment of osteoarthritis and the preservation of cartilage. They are also promising ROS scavengers and may be used to fabricate antioxidant polymer microreactors. In cancer treatment, the MnO2 nanoparticles inhibit ATP production by cancer cells. In magnetic resonance imaging, the nanoparticles improve the signal-to-noise ratio and selectivity. Based on this background information, MnO2 nanoparticles today find use in photodynamic, chemodynamic, and immune therapy and diagnostics, where the oxygen produced by MnO2 nanoparticles is said to improve the therapeutic efficiency. Hybrid nanoparticles of gold nanorods and MnO2 nanoparticles enhance the performance in hormone-, pH-, and NIR- responsiveness. Other applications include glucose oxidase activity, photothermal conversion, and enhanced antitumor immunity. On the other hand, the nanoparticles can cause spermatogenesis failure, oxidative stress, active oxygen, and sperm motility reduction. As surface functionalization can improve the overall functional properties of the nanoparticles, polymer coating on MnO2 nanoparticles brings about new and improved properties. For instance, the layer of biopolymers such as chitosan enhances the magnetic resonance images’ quality and opens up the potential for attaching drugs and targeting moieties.https://nmj.mums.ac.ir/article_21163_c6266214ae9f3da89c15076cc62ead59.pdfbiopolymersbiomedical applicationsmetal nanoparticlemutagenicity |
| spellingShingle | Jino Affrald R Nandhini M Shoba Narayan A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity Nanomedicine Journal biopolymers biomedical applications metal nanoparticle mutagenicity |
| title | A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| title_full | A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| title_fullStr | A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| title_full_unstemmed | A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| title_short | A comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| title_sort | comprehensive review of manganese dioxide nanoparticles and strategy to overcome toxicity |
| topic | biopolymers biomedical applications metal nanoparticle mutagenicity |
| url | https://nmj.mums.ac.ir/article_21163_c6266214ae9f3da89c15076cc62ead59.pdf |
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