Association of serum oleic acid level with depression in American adults: a cross-sectional study
Abstract Background As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent. Methods This cross-sectional study analyzed 4,459 adult...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-05271-0 |
| _version_ | 1797557379204644864 |
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| author | Jiahui Yin Siyuan Li Jinling Li Rongpeng Gong Zhixia Jia Junjun Liu Zhi Jin Jiguo Yang Yuanxiang Liu |
| author_facet | Jiahui Yin Siyuan Li Jinling Li Rongpeng Gong Zhixia Jia Junjun Liu Zhi Jin Jiguo Yang Yuanxiang Liu |
| author_sort | Jiahui Yin |
| collection | DOAJ |
| description | Abstract Background As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent. Methods This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011–2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol. Results Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16–1.57; adjusted OR: 1.40, 95% CI: 1.03–1.90). Conclusions Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression. |
| first_indexed | 2024-03-10T17:16:12Z |
| format | Article |
| id | doaj.art-5f3f77128db5455d80746d0bf8fb4764 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:12Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-5f3f77128db5455d80746d0bf8fb47642023-11-20T10:29:33ZengBMCBMC Psychiatry1471-244X2023-11-012311910.1186/s12888-023-05271-0Association of serum oleic acid level with depression in American adults: a cross-sectional studyJiahui Yin0Siyuan Li1Jinling Li2Rongpeng Gong3Zhixia Jia4Junjun Liu5Zhi Jin6Jiguo Yang7Yuanxiang Liu8College of Traditional Chinese Medicine, Shandong University of Traditional Chinese MedicineDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineCollege of Acupuncture and Massage, Shandong University of Traditional Chinese MedicineRWTH Aachen UniversityFirst Clinical Medical College, Shandong University of Traditional Chinese MedicineNanjing Meishan HospitalDepartment of Neurology, Shanghai Fifth People’s Hospital, Fudan UniversityCollege of Acupuncture and Massage, Shandong University of Traditional Chinese MedicineDepartment of Neurology, Shandong University of Traditional Chinese Medicine Affiliated HospitalAbstract Background As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent. Methods This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011–2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol. Results Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16–1.57; adjusted OR: 1.40, 95% CI: 1.03–1.90). Conclusions Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.https://doi.org/10.1186/s12888-023-05271-0DepressionOleic acidFatty acidCross-sectional study |
| spellingShingle | Jiahui Yin Siyuan Li Jinling Li Rongpeng Gong Zhixia Jia Junjun Liu Zhi Jin Jiguo Yang Yuanxiang Liu Association of serum oleic acid level with depression in American adults: a cross-sectional study BMC Psychiatry Depression Oleic acid Fatty acid Cross-sectional study |
| title | Association of serum oleic acid level with depression in American adults: a cross-sectional study |
| title_full | Association of serum oleic acid level with depression in American adults: a cross-sectional study |
| title_fullStr | Association of serum oleic acid level with depression in American adults: a cross-sectional study |
| title_full_unstemmed | Association of serum oleic acid level with depression in American adults: a cross-sectional study |
| title_short | Association of serum oleic acid level with depression in American adults: a cross-sectional study |
| title_sort | association of serum oleic acid level with depression in american adults a cross sectional study |
| topic | Depression Oleic acid Fatty acid Cross-sectional study |
| url | https://doi.org/10.1186/s12888-023-05271-0 |
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