Dynamical Systems Models for Plasma Dilution
Introduction: Recent experiments provide evidence that diluting the blood plasma restores the plasma environment to a more youthful level at least partially restoring the health of organs and tissues throughout the body. Objectives: We analyze whether a dynamical-systems model representing the pla...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2022-10-01
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| Series: | Re:GEN Open |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/REGEN.2022.0048 |
| _version_ | 1797346088123891712 |
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| author | Dylan Chambers Neil Christensen |
| author_facet | Dylan Chambers Neil Christensen |
| author_sort | Dylan Chambers |
| collection | DOAJ |
| description |
Introduction: Recent experiments provide evidence that diluting the blood plasma restores the plasma environment to a more youthful level at least partially restoring the health of organs and tissues throughout the body.
Objectives: We analyze whether a dynamical-systems model representing the plasma constituents could support the optimization process and help determine the appropriate dilution level, frequency and any simultaneous plasma infusions to achieve the most favorable outcome.
Methods: We use a combination of a gradient descent, a simulated annealing and a genetic algorithm to find a population of models that fit illustrative data.
Results: We analyze this population and present distributions of the model parameters and include a collection of plots of the dilution process for illustrative models.
Conclusions: We find that, if we had more data to disambiguate the models, these dynmical-systems models could give useful predictions for plasma-dilution/addition experiments as well as support the interpretation of their results. |
| first_indexed | 2024-03-08T11:26:46Z |
| format | Article |
| id | doaj.art-5f3f83675fbb483aa19396acf402df20 |
| institution | Directory Open Access Journal |
| issn | 2766-2705 |
| language | English |
| last_indexed | 2024-03-08T11:26:46Z |
| publishDate | 2022-10-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Re:GEN Open |
| spelling | doaj.art-5f3f83675fbb483aa19396acf402df202024-01-26T05:14:36ZengMary Ann LiebertRe:GEN Open2766-27052022-10-012111013510.1089/REGEN.2022.0048Dynamical Systems Models for Plasma DilutionDylan Chambers0Neil Christensen1Department of Physics, Illinois State UniversityDepartment of Physics, Illinois State University Introduction: Recent experiments provide evidence that diluting the blood plasma restores the plasma environment to a more youthful level at least partially restoring the health of organs and tissues throughout the body. Objectives: We analyze whether a dynamical-systems model representing the plasma constituents could support the optimization process and help determine the appropriate dilution level, frequency and any simultaneous plasma infusions to achieve the most favorable outcome. Methods: We use a combination of a gradient descent, a simulated annealing and a genetic algorithm to find a population of models that fit illustrative data. Results: We analyze this population and present distributions of the model parameters and include a collection of plots of the dilution process for illustrative models. Conclusions: We find that, if we had more data to disambiguate the models, these dynmical-systems models could give useful predictions for plasma-dilution/addition experiments as well as support the interpretation of their results.https://www.liebertpub.com/doi/full/10.1089/REGEN.2022.0048agingcomputational biologyplasmapheresisrejuvenationdynamical systems |
| spellingShingle | Dylan Chambers Neil Christensen Dynamical Systems Models for Plasma Dilution Re:GEN Open aging computational biology plasmapheresis rejuvenation dynamical systems |
| title | Dynamical Systems Models for Plasma Dilution |
| title_full | Dynamical Systems Models for Plasma Dilution |
| title_fullStr | Dynamical Systems Models for Plasma Dilution |
| title_full_unstemmed | Dynamical Systems Models for Plasma Dilution |
| title_short | Dynamical Systems Models for Plasma Dilution |
| title_sort | dynamical systems models for plasma dilution |
| topic | aging computational biology plasmapheresis rejuvenation dynamical systems |
| url | https://www.liebertpub.com/doi/full/10.1089/REGEN.2022.0048 |
| work_keys_str_mv | AT dylanchambers dynamicalsystemsmodelsforplasmadilution AT neilchristensen dynamicalsystemsmodelsforplasmadilution |