Effect of inverted internal limiting membrane flap technique on small-medium size macular holes
Abstract Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH and refractory cases. In this study, we evaluate the effect of the technique for small-medium size MH. We recruited patients who underwent vitrectomy for small-medium size...
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| Format: | Article |
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-04739-x |
| _version_ | 1818753460465565696 |
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| author | Kanako Yamada Akio Oishi Mao Kusano Hirofumi Kinoshita Eiko Tsuiki Takashi Kitaoka |
| author_facet | Kanako Yamada Akio Oishi Mao Kusano Hirofumi Kinoshita Eiko Tsuiki Takashi Kitaoka |
| author_sort | Kanako Yamada |
| collection | DOAJ |
| description | Abstract Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH and refractory cases. In this study, we evaluate the effect of the technique for small-medium size MH. We recruited patients who underwent vitrectomy for small-medium size (< 400 μm) MH with either inverted ILM flap technique (flap group) or with conventional ILM peeling (peeling group). Using propensity score, 21 eyes of 21 patients in the peeling group were matched against 21 eyes of 21 patients in the flap group. We compared MH closure rate, postoperative visual acuity, and recovery of the external limiting membrane (ELM) and ellipsoid zone (EZ). The MH closure rate was not different between the two groups (flap vs peeling: 90% vs 100%, P = 0.49). Whereas there was no significant difference in visual acuity improvement between the two groups, the flap group showed more disruption of the ELM 3 months after surgery and of the EZ at 3 and 6 months after surgery (P = 0.02, P = 0.03, and P = 0.04, respectively). The result suggested that inverted ILM flap technique does not have additional benefits for small-medium size MHs and may delay recovery of retinal integrity. |
| first_indexed | 2024-12-18T05:07:43Z |
| format | Article |
| id | doaj.art-5f40fee795ec4abc945fad9afcb768e1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:07:43Z |
| publishDate | 2022-01-01 |
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| series | Scientific Reports |
| spelling | doaj.art-5f40fee795ec4abc945fad9afcb768e12022-12-21T21:19:58ZengNature PortfolioScientific Reports2045-23222022-01-011211710.1038/s41598-021-04739-xEffect of inverted internal limiting membrane flap technique on small-medium size macular holesKanako Yamada0Akio Oishi1Mao Kusano2Hirofumi Kinoshita3Eiko Tsuiki4Takashi Kitaoka5Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki UniversityAbstract Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH and refractory cases. In this study, we evaluate the effect of the technique for small-medium size MH. We recruited patients who underwent vitrectomy for small-medium size (< 400 μm) MH with either inverted ILM flap technique (flap group) or with conventional ILM peeling (peeling group). Using propensity score, 21 eyes of 21 patients in the peeling group were matched against 21 eyes of 21 patients in the flap group. We compared MH closure rate, postoperative visual acuity, and recovery of the external limiting membrane (ELM) and ellipsoid zone (EZ). The MH closure rate was not different between the two groups (flap vs peeling: 90% vs 100%, P = 0.49). Whereas there was no significant difference in visual acuity improvement between the two groups, the flap group showed more disruption of the ELM 3 months after surgery and of the EZ at 3 and 6 months after surgery (P = 0.02, P = 0.03, and P = 0.04, respectively). The result suggested that inverted ILM flap technique does not have additional benefits for small-medium size MHs and may delay recovery of retinal integrity.https://doi.org/10.1038/s41598-021-04739-x |
| spellingShingle | Kanako Yamada Akio Oishi Mao Kusano Hirofumi Kinoshita Eiko Tsuiki Takashi Kitaoka Effect of inverted internal limiting membrane flap technique on small-medium size macular holes Scientific Reports |
| title | Effect of inverted internal limiting membrane flap technique on small-medium size macular holes |
| title_full | Effect of inverted internal limiting membrane flap technique on small-medium size macular holes |
| title_fullStr | Effect of inverted internal limiting membrane flap technique on small-medium size macular holes |
| title_full_unstemmed | Effect of inverted internal limiting membrane flap technique on small-medium size macular holes |
| title_short | Effect of inverted internal limiting membrane flap technique on small-medium size macular holes |
| title_sort | effect of inverted internal limiting membrane flap technique on small medium size macular holes |
| url | https://doi.org/10.1038/s41598-021-04739-x |
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