Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate
Hydrophobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent molecules, which then act as acceptors for one of the three H...
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| Format: | Article |
| Language: | English |
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International Union of Crystallography
2016-05-01
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| Series: | Acta Crystallographica Section E: Crystallographic Communications |
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| Online Access: | http://scripts.iucr.org/cgi-bin/paper?S2056989016005302 |
| _version_ | 1818321628803629056 |
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| author | Carl Henrik Görbitz |
| author_facet | Carl Henrik Görbitz |
| author_sort | Carl Henrik Görbitz |
| collection | DOAJ |
| description | Hydrophobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent molecules, which then act as acceptors for one of the three H atoms of the charged N-terminal amino group. l-Leu-l-Ile has uniquely been obtained as two distinct hydrates, but has so far failed to co-crystallize with a simple alcohol. The present structure of C12H24N2O3·CF3CH2OH, which crystallizes with two dipeptide and two solvent molecules in the asymmetric unit, demonstrates that when 2,2,2-trifluoroethanol is used as a solvent, its high capacity as a hydrogen-bond donor leads to formation of an alcohol solvate. |
| first_indexed | 2024-12-13T10:43:56Z |
| format | Article |
| id | doaj.art-5f4188ae62e54177a40c74df52b51efe |
| institution | Directory Open Access Journal |
| issn | 2056-9890 |
| language | English |
| last_indexed | 2024-12-13T10:43:56Z |
| publishDate | 2016-05-01 |
| publisher | International Union of Crystallography |
| record_format | Article |
| series | Acta Crystallographica Section E: Crystallographic Communications |
| spelling | doaj.art-5f4188ae62e54177a40c74df52b51efe2022-12-21T23:50:20ZengInternational Union of CrystallographyActa Crystallographica Section E: Crystallographic Communications2056-98902016-05-0172563563810.1107/S2056989016005302hb7570Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvateCarl Henrik Görbitz0Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N-0315 Oslo, NorwayHydrophobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent molecules, which then act as acceptors for one of the three H atoms of the charged N-terminal amino group. l-Leu-l-Ile has uniquely been obtained as two distinct hydrates, but has so far failed to co-crystallize with a simple alcohol. The present structure of C12H24N2O3·CF3CH2OH, which crystallizes with two dipeptide and two solvent molecules in the asymmetric unit, demonstrates that when 2,2,2-trifluoroethanol is used as a solvent, its high capacity as a hydrogen-bond donor leads to formation of an alcohol solvate.http://scripts.iucr.org/cgi-bin/paper?S2056989016005302dipeptidehead-to-tail chainshydrogen bondslayered structurecrystal structure |
| spellingShingle | Carl Henrik Görbitz Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate Acta Crystallographica Section E: Crystallographic Communications dipeptide head-to-tail chains hydrogen bonds layered structure crystal structure |
| title | Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate |
| title_full | Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate |
| title_fullStr | Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate |
| title_full_unstemmed | Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate |
| title_short | Crystal structure of l-leucyl-l-isoleucine 2,2,2-trifluoroethanol monosolvate |
| title_sort | crystal structure of l leucyl l isoleucine 2 2 2 trifluoroethanol monosolvate |
| topic | dipeptide head-to-tail chains hydrogen bonds layered structure crystal structure |
| url | http://scripts.iucr.org/cgi-bin/paper?S2056989016005302 |
| work_keys_str_mv | AT carlhenrikgorbitz crystalstructureoflleucyllisoleucine222trifluoroethanolmonosolvate |