Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
Background: The prognostic-related factors of lung invasive mucinous adenocarcinoma(IMA) are unclear because of its rarity. Various inflammation-based biomarkers were reported to predict the survival of malignant diseases. This study aims to explore the prognostic significance of the systemic immune...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523323002516 |
| _version_ | 1797355284859977728 |
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| author | Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu |
| author_facet | Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu |
| author_sort | Wei Sun |
| collection | DOAJ |
| description | Background: The prognostic-related factors of lung invasive mucinous adenocarcinoma(IMA) are unclear because of its rarity. Various inflammation-based biomarkers were reported to predict the survival of malignant diseases. This study aims to explore the prognostic significance of the systemic immune-inflammation index(SII), which is calculated using absolute platelet, neutrophil, and lymphocyte counts, among patients with invasive mucinous adenocarcinoma. Methods: From January 2015 to December 2019, 106 patients were identified as having IMA accepted radical resection and enrolled in the retrospective study. We analyzed the overall survival and disease-free survival using the Kaplan-Meier method and log-rank test. Receiver operating characteristic curve was used to find the optimal SII cut-off values for survival. A Cox regression model was carried out for multivariable analyses. Results: The study cohort included 53 men and 53 women, with a mean age of 60 years (range 29 to 78 years, median 61 years). The median SII measured before surgery was 378.47 (range: 79.87–1701.97). ROC analyses revealed that the optimal cut-off values of SII was 379.43 for predicting both OS and DFS. An elevated SII (≥379.43) was observed in 52 patients (49.1 %), and was associated with younger age (P = 0.02), advanced T staging (P = 0.042), lymph node metastasis (P = 0.018) and pneumonic-type IMA (P = 0.018). Multivariable analysis showed that SII and pneumonic-type IMA were independent prognostic predictors of OS and DFS in radically resected IMA patients (P < 0.05). Conclusion: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery. |
| first_indexed | 2024-03-08T14:08:57Z |
| format | Article |
| id | doaj.art-5f45a0de16fd416f8fe4d3ece1ac902a |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-03-08T14:08:57Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-5f45a0de16fd416f8fe4d3ece1ac902a2024-01-15T04:22:20ZengElsevierTranslational Oncology1936-52332024-02-0140101865Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinomaWei Sun0Pengpeng Zhang1Bicheng Ye2Min-Yi Situ3Wei Wang4Yue Yu5Department of Thoracic Surgery, The Second Hospital of Nanjing, Nanjing, ChinaDepartment of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Lung Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, ChinaSchool of Clinical Medicine, Yangzhou Polytechnic College, Yangzhou, ChinaSun Yat-sen University Cancer Center, Guangzhou, China; Corresponding author.Department of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.Department of Thoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.Background: The prognostic-related factors of lung invasive mucinous adenocarcinoma(IMA) are unclear because of its rarity. Various inflammation-based biomarkers were reported to predict the survival of malignant diseases. This study aims to explore the prognostic significance of the systemic immune-inflammation index(SII), which is calculated using absolute platelet, neutrophil, and lymphocyte counts, among patients with invasive mucinous adenocarcinoma. Methods: From January 2015 to December 2019, 106 patients were identified as having IMA accepted radical resection and enrolled in the retrospective study. We analyzed the overall survival and disease-free survival using the Kaplan-Meier method and log-rank test. Receiver operating characteristic curve was used to find the optimal SII cut-off values for survival. A Cox regression model was carried out for multivariable analyses. Results: The study cohort included 53 men and 53 women, with a mean age of 60 years (range 29 to 78 years, median 61 years). The median SII measured before surgery was 378.47 (range: 79.87–1701.97). ROC analyses revealed that the optimal cut-off values of SII was 379.43 for predicting both OS and DFS. An elevated SII (≥379.43) was observed in 52 patients (49.1 %), and was associated with younger age (P = 0.02), advanced T staging (P = 0.042), lymph node metastasis (P = 0.018) and pneumonic-type IMA (P = 0.018). Multivariable analysis showed that SII and pneumonic-type IMA were independent prognostic predictors of OS and DFS in radically resected IMA patients (P < 0.05). Conclusion: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.http://www.sciencedirect.com/science/article/pii/S1936523323002516Invasive mucinous adenocarcinoma(IMA)Lung, prognosisSystemic immune-inflammation index(SII)Surgery |
| spellingShingle | Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma Translational Oncology Invasive mucinous adenocarcinoma(IMA) Lung, prognosis Systemic immune-inflammation index(SII) Surgery |
| title | Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| title_full | Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| title_fullStr | Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| title_full_unstemmed | Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| title_short | Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| title_sort | systemic immune inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma |
| topic | Invasive mucinous adenocarcinoma(IMA) Lung, prognosis Systemic immune-inflammation index(SII) Surgery |
| url | http://www.sciencedirect.com/science/article/pii/S1936523323002516 |
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