Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada
Receipt of fluoroquinolones was the predominant risk factor for Clostridium difficile–associated disease (CDAD) during an epidemic in Quebec, Canada. To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2006-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/12/9/06-0397_article |
| _version_ | 1819011651332997120 |
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| author | Louiselle LeBlanc Jacques Pépin Krystel Toulouse Marie-France Ouellette Marie-Andrée Coulombe Marie-Pier Corriveau Marie-Eve Alary |
| author_facet | Louiselle LeBlanc Jacques Pépin Krystel Toulouse Marie-France Ouellette Marie-Andrée Coulombe Marie-Pier Corriveau Marie-Eve Alary |
| author_sort | Louiselle LeBlanc |
| collection | DOAJ |
| description | Receipt of fluoroquinolones was the predominant risk factor for Clostridium difficile–associated disease (CDAD) during an epidemic in Quebec, Canada. To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection and to compare this role with their effects on methicillin-susceptible S. aureus infection and CDAD, we conducted a retrospective cohort study of patients in a Quebec hospital. For 7,371 episodes of care, data were collected on risk factors, including receipt of antimicrobial drugs. Crude and adjusted hazard ratios (AHR) were calculated by Cox regression. Of 150 episodes of MRSA colonization and 23 of MRSA infection, fluoroquinolones were the only antimicrobials that increased risk for colonization (AHR 2.57, 95% confidence interval [CI] 1.84–3.60) and infection (AHR 2.49, 95% CI 1.02–6.07). Effect of antimicrobial drugs on MRSA colonization and infection was similar to effect on CDAD and should be considered when selecting antimicrobial drugs to treat common infections. |
| first_indexed | 2024-12-21T01:31:33Z |
| format | Article |
| id | doaj.art-5f46f4eee2be4d769236340a3e251378 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-21T01:31:33Z |
| publishDate | 2006-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-5f46f4eee2be4d769236340a3e2513782022-12-21T19:20:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-09-011291398140510.3201/eid1209.060397Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, CanadaLouiselle LeBlancJacques PépinKrystel ToulouseMarie-France OuelletteMarie-Andrée CoulombeMarie-Pier CorriveauMarie-Eve AlaryReceipt of fluoroquinolones was the predominant risk factor for Clostridium difficile–associated disease (CDAD) during an epidemic in Quebec, Canada. To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection and to compare this role with their effects on methicillin-susceptible S. aureus infection and CDAD, we conducted a retrospective cohort study of patients in a Quebec hospital. For 7,371 episodes of care, data were collected on risk factors, including receipt of antimicrobial drugs. Crude and adjusted hazard ratios (AHR) were calculated by Cox regression. Of 150 episodes of MRSA colonization and 23 of MRSA infection, fluoroquinolones were the only antimicrobials that increased risk for colonization (AHR 2.57, 95% confidence interval [CI] 1.84–3.60) and infection (AHR 2.49, 95% CI 1.02–6.07). Effect of antimicrobial drugs on MRSA colonization and infection was similar to effect on CDAD and should be considered when selecting antimicrobial drugs to treat common infections.https://wwwnc.cdc.gov/eid/article/12/9/06-0397_articlemethicillin-resistant Staphylococcus aureusmethicillin-susceptible Staphylococcus aureusfluoroquinolonesCanadaresearch |
| spellingShingle | Louiselle LeBlanc Jacques Pépin Krystel Toulouse Marie-France Ouellette Marie-Andrée Coulombe Marie-Pier Corriveau Marie-Eve Alary Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada Emerging Infectious Diseases methicillin-resistant Staphylococcus aureus methicillin-susceptible Staphylococcus aureus fluoroquinolones Canada research |
| title | Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada |
| title_full | Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada |
| title_fullStr | Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada |
| title_full_unstemmed | Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada |
| title_short | Fluoroquinolones and Risk for Methicillin-Resistant Staphylococcus aureus, Canada |
| title_sort | fluoroquinolones and risk for methicillin resistant staphylococcus aureus canada |
| topic | methicillin-resistant Staphylococcus aureus methicillin-susceptible Staphylococcus aureus fluoroquinolones Canada research |
| url | https://wwwnc.cdc.gov/eid/article/12/9/06-0397_article |
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