Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Iron deprivation activates mitophagy and extends lifespan in nematodes. In patients suffering from Parkinson’s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan. To evaluate molecular effects of iron chelator drugs as a potential PD therapy, we...

Full description

Bibliographic Details
Main Authors: Jana Key, Nesli Ece Sen, Aleksandar Arsović, Stella Krämer, Robert Hülse, Natasha Nadeem Khan, David Meierhofer, Suzana Gispert, Gabriele Koepf, Georg Auburger
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
synuclein
CPT1A
MMP14
PYGL
<i>Tfrc</i>
<i>Ireb2</i>
Online Access:https://www.mdpi.com/2073-4409/9/10/2229

Internet

https://www.mdpi.com/2073-4409/9/10/2229

Similar Items