The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

Abstract Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer-associated fibroblasts (CAFs) to feed...

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Bibliographic Details
Main Authors: Samaneh Mostafavi, Hamidreza Zalpoor, Zuhair Mohammad Hassan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Tumor microenvironment
Myofibroblasts
Cancer-associated fibroblasts
Metformin
Lactic acid
Stromal cells
Online Access:https://doi.org/10.1186/s11658-022-00356-2

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