The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism

The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism

Human cytomegalovirus (HCMV) is a major human pathogen associated with severe pathology. Current options of antiviral therapy only partly satisfy the needs of a well-tolerated long-term treatment/prophylaxis free from drug-induced viral resistance. Recently, we reported the strong antiviral properti...

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Bibliographic Details
Main Authors: Markus Wild, Friedrich Hahn, Benedikt Grau, Lars Herrmann, Aischa Niesar, Martin Schütz, Melanie M. Lorion, Lutz Ackermann, Svetlana B. Tsogoeva, Manfred Marschall
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
human cytomegalovirus
antiviral drugs
artemisinin derivative
autofluorescence
intracellular tracking
mitochondrial impairment
Online Access:https://www.mdpi.com/1422-0067/21/15/5578

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