Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies

Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies

Introduction:In vitro approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these in vitro assessments, it is advocated to remove animal-derived products such as foetal bovine serum (FBS) from th...

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Bibliographic Details
Main Authors: Noelia Perez-Diaz, Ewelina Hoffman, Julie Clements, Rebecca Cruickshank, Ann Doherty, Daniel Ebner, Joanne Elloway, Jianan Fu, Joanne Kelsall, Val Millar, Ouarda Saib, Andrew Scott, Ian Woods, Victoria Hutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Toxicology
Subjects:
chemically defined serum replacement
fetal bovine serum
FBS replacement
sequential adaptation
TK6
OECD
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2023.1177586/full

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