Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis
Abstract Background Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific difference...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13601-017-0176-5 |
| _version_ | 1818367524592418816 |
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| author | M. Fröhlich M. Pinart T. Keller A. Reich B. Cabieses C. Hohmann D. S. Postma J. Bousquet J. M. Antó T. Keil S. Roll |
| author_facet | M. Fröhlich M. Pinart T. Keller A. Reich B. Cabieses C. Hohmann D. S. Postma J. Bousquet J. M. Antó T. Keil S. Roll |
| author_sort | M. Fröhlich |
| collection | DOAJ |
| description | Abstract Background Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Methods Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male–female ratios for coexisting allergic rhinitis and asthma in children (0–10 years), adolescents (11–17) and adults (> 17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000–2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratified by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. Results From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male–female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N = 6 studies), 0.61 (0.51; 0.72) in adolescents (N = 2) and 1.03 (0.79; 1.35) in adults (N = 2). Male–female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N = 5) in children, 0.80 (0.71; 0.89, N = 2) in adolescents and 0.98 (0.74; 1.30, N = 2) in adults, respectively. Conclusions The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only. |
| first_indexed | 2024-12-13T22:53:25Z |
| format | Article |
| id | doaj.art-5f4c2c9840324365a0776a55a2d49c38 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-13T22:53:25Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-5f4c2c9840324365a0776a55a2d49c382022-12-21T23:28:34ZengWileyClinical and Translational Allergy2045-70222017-12-01711910.1186/s13601-017-0176-5Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysisM. Fröhlich0M. Pinart1T. Keller2A. Reich3B. Cabieses4C. Hohmann5D. S. Postma6J. Bousquet7J. M. Antó8T. Keil9S. Roll10Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinEpidemiology, German Rheumatism Research CentreFacultad de Medicina Clínica Alemana, Universidad del DesarrolloInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinDepartment of Pulmonology, University Medical Center Groningen, University of GroningenUniversity HospitalISGlobal, Centre for Research in Environmental Epidemiology (CREAL)Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin BerlinAbstract Background Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Methods Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male–female ratios for coexisting allergic rhinitis and asthma in children (0–10 years), adolescents (11–17) and adults (> 17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000–2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratified by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. Results From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male–female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N = 6 studies), 0.61 (0.51; 0.72) in adolescents (N = 2) and 1.03 (0.79; 1.35) in adults (N = 2). Male–female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N = 5) in children, 0.80 (0.71; 0.89, N = 2) in adolescents and 0.98 (0.74; 1.30, N = 2) in adults, respectively. Conclusions The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only.http://link.springer.com/article/10.1186/s13601-017-0176-5Allergic rhinitisAsthmaMultimorbidityPrevalenceSystematic review |
| spellingShingle | M. Fröhlich M. Pinart T. Keller A. Reich B. Cabieses C. Hohmann D. S. Postma J. Bousquet J. M. Antó T. Keil S. Roll Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis Clinical and Translational Allergy Allergic rhinitis Asthma Multimorbidity Prevalence Systematic review |
| title | Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis |
| title_full | Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis |
| title_fullStr | Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis |
| title_full_unstemmed | Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis |
| title_short | Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis |
| title_sort | is there a sex shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood a meta analysis |
| topic | Allergic rhinitis Asthma Multimorbidity Prevalence Systematic review |
| url | http://link.springer.com/article/10.1186/s13601-017-0176-5 |
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