Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study

Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study

Abstract Background Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimicked ASGR1 inhibitors on all-cause mortality and any possible adverse eff...

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Bibliographic Details
Main Authors: Guoyi Yang, C. Mary Schooling
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Medicine
Subjects:
All-cause mortality
ASGR1 inhibitors
Mendelian randomization
Phenome-wide association study
Cardiovascular disease
Online Access:https://doi.org/10.1186/s12916-023-02903-w

Internet

https://doi.org/10.1186/s12916-023-02903-w

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