A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics
The present research work intended to demonstrate the green synthesis of silver nanoparticles (AgNPs) using the plant extract <i>Saccharum officinarum</i>, and then the development of chitosan–silver (CH-Ag) bionanocomposite. The synthesized AgNPs were characterized using UV spectroscopy...
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MDPI AG
2022-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/9/1911 |
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| author | Saruchi Manpreet Kaur Vaneet Kumar Ayman A. Ghfar Sadanand Pandey |
| author_facet | Saruchi Manpreet Kaur Vaneet Kumar Ayman A. Ghfar Sadanand Pandey |
| author_sort | Saruchi |
| collection | DOAJ |
| description | The present research work intended to demonstrate the green synthesis of silver nanoparticles (AgNPs) using the plant extract <i>Saccharum officinarum</i>, and then the development of chitosan–silver (CH-Ag) bionanocomposite. The synthesized AgNPs were characterized using UV spectroscopy, Fourier transform infrared (FTIR), and transmission electron microscopy (TEM). The maximum absorption spectrum peak was observed at 420 nm, revealing the formation of AgNPs by the stem extract of <i>S. officinarum</i>. The AgNPs sizes were in the range of 10–50 nm. Itraconazole is an antifungal that is used as a novel drug to study its release through synthesized bionanocomposite. Different kinetic models, such as zero order, first order, Korsmeyer–Peppas, Hixson–Crowell and Higuchi, were used to study the drug release profile from the synthesized CH-Ag bionanocomposite. The first-order kinetic model showed the best fit for the drug release with the maximum regression coefficient value. The antibacterial activity of the synthesized CH-Ag bionanocomposite was examined against <i>Bacillus cereus</i>, <i>Staphylococcus</i>, and <i>Escherichia coli</i>, and it was shown to be efficient against these strains. |
| first_indexed | 2024-03-10T03:45:52Z |
| format | Article |
| id | doaj.art-5f50f84f5f6742e287d1bb9cd5afe6a7 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:45:52Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5f50f84f5f6742e287d1bb9cd5afe6a72023-11-23T09:08:07ZengMDPI AGPolymers2073-43602022-05-01149191110.3390/polym14091911A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial CharacteristicsSaruchi0Manpreet Kaur1Vaneet Kumar2Ayman A. Ghfar3Sadanand Pandey4Department of Biotechnology, CT Institute of Pharmaceutical Sciences, Shahpur Campus, Jalandhar 144008, Punjab, IndiaDepartment of Biotechnology, CT Institute of Pharmaceutical Sciences, Shahpur Campus, Jalandhar 144008, Punjab, IndiaDepartment of Applied Sciences, CT Institute of Engineering, Management and Technology, Shahpur Campus, Jalandhar 144623, Punjab, IndiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Natural Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, KoreaThe present research work intended to demonstrate the green synthesis of silver nanoparticles (AgNPs) using the plant extract <i>Saccharum officinarum</i>, and then the development of chitosan–silver (CH-Ag) bionanocomposite. The synthesized AgNPs were characterized using UV spectroscopy, Fourier transform infrared (FTIR), and transmission electron microscopy (TEM). The maximum absorption spectrum peak was observed at 420 nm, revealing the formation of AgNPs by the stem extract of <i>S. officinarum</i>. The AgNPs sizes were in the range of 10–50 nm. Itraconazole is an antifungal that is used as a novel drug to study its release through synthesized bionanocomposite. Different kinetic models, such as zero order, first order, Korsmeyer–Peppas, Hixson–Crowell and Higuchi, were used to study the drug release profile from the synthesized CH-Ag bionanocomposite. The first-order kinetic model showed the best fit for the drug release with the maximum regression coefficient value. The antibacterial activity of the synthesized CH-Ag bionanocomposite was examined against <i>Bacillus cereus</i>, <i>Staphylococcus</i>, and <i>Escherichia coli</i>, and it was shown to be efficient against these strains.https://www.mdpi.com/2073-4360/14/9/1911<i>Saccharum officinarum</i>silver nanoparticleschitosanbionanocompositeantibacterial activity |
| spellingShingle | Saruchi Manpreet Kaur Vaneet Kumar Ayman A. Ghfar Sadanand Pandey A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics Polymers <i>Saccharum officinarum</i> silver nanoparticles chitosan bionanocomposite antibacterial activity |
| title | A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics |
| title_full | A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics |
| title_fullStr | A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics |
| title_full_unstemmed | A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics |
| title_short | A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics |
| title_sort | green approach for the synthesis of silver nanoparticle embedded chitosan bionanocomposite as a potential device for the sustained release of the itraconazole drug and its antibacterial characteristics |
| topic | <i>Saccharum officinarum</i> silver nanoparticles chitosan bionanocomposite antibacterial activity |
| url | https://www.mdpi.com/2073-4360/14/9/1911 |
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