The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis
Objective It is of great importance to recognize bio-markers for cancer prognosis. However, the association between solute carrier family 7 member 11 (SLC7A11) and prognosis is still controversial. Therefore, we conducted this systematic review and meta-analysis to identify the prognostic and clinic...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2023-02-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/14931.pdf |
| _version_ | 1827610907667070976 |
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| author | Jiantao Wang Siyuan Hao Guojiao Song Yan Wang Qiukui Hao |
| author_facet | Jiantao Wang Siyuan Hao Guojiao Song Yan Wang Qiukui Hao |
| author_sort | Jiantao Wang |
| collection | DOAJ |
| description | Objective It is of great importance to recognize bio-markers for cancer prognosis. However, the association between solute carrier family 7 member 11 (SLC7A11) and prognosis is still controversial. Therefore, we conducted this systematic review and meta-analysis to identify the prognostic and clinicopathological significance of SLC7A11 in human cancers. Methods PubMed, Web of Science, Scopus, the Cochrane Library and Embase database were searched from database inceptions to March 19th 2022. Hand searches were also conducted in references. Prognosis and clinicopathological data were extracted and analyzed. Results A total of 12 eligible studies with 1,955 patients were included. The results indicated that SLC7A11 expression is associated with unfavorable overall survival (OS), unfavorable recurrence-free survival (RFS) and unfavorable progression free survival (PFS). And SLC7A11 expression is also associated with more advanced tumor stage. Conclusions SLC7A11 expression is associated with more unfavorable prognosis and more advanced tumor stage. Therefore, SLC7A11 could be a potential biomarker for human cancer prognosis. |
| first_indexed | 2024-03-09T07:57:31Z |
| format | Article |
| id | doaj.art-5f51938de44c4bcbb28bbcb7a5f840ab |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:57:31Z |
| publishDate | 2023-02-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-5f51938de44c4bcbb28bbcb7a5f840ab2023-12-03T00:52:31ZengPeerJ Inc.PeerJ2167-83592023-02-0111e1493110.7717/peerj.14931The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysisJiantao Wang0Siyuan Hao1Guojiao Song2Yan Wang3Qiukui Hao4Sichuan University, State Key Laboratory of Biotherapy & Department of Lung Cancer Center and Department of Radiation Oncology, West China Hospital, Chengdu, ChinaSichuan University, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, ChinaSichuan University, State Key Laboratory of Biotherapy & Department of Lung Cancer Center and Department of Radiation Oncology, West China Hospital, Chengdu, ChinaSichuan University, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, ChinaMcMaster University, Faculty of Health Sciences, School of Rehabilitation Science, Ontario, CanadaObjective It is of great importance to recognize bio-markers for cancer prognosis. However, the association between solute carrier family 7 member 11 (SLC7A11) and prognosis is still controversial. Therefore, we conducted this systematic review and meta-analysis to identify the prognostic and clinicopathological significance of SLC7A11 in human cancers. Methods PubMed, Web of Science, Scopus, the Cochrane Library and Embase database were searched from database inceptions to March 19th 2022. Hand searches were also conducted in references. Prognosis and clinicopathological data were extracted and analyzed. Results A total of 12 eligible studies with 1,955 patients were included. The results indicated that SLC7A11 expression is associated with unfavorable overall survival (OS), unfavorable recurrence-free survival (RFS) and unfavorable progression free survival (PFS). And SLC7A11 expression is also associated with more advanced tumor stage. Conclusions SLC7A11 expression is associated with more unfavorable prognosis and more advanced tumor stage. Therefore, SLC7A11 could be a potential biomarker for human cancer prognosis.https://peerj.com/articles/14931.pdfSLC7A11CancerPrognosisSystematic reviewMeta-analysis |
| spellingShingle | Jiantao Wang Siyuan Hao Guojiao Song Yan Wang Qiukui Hao The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis PeerJ SLC7A11 Cancer Prognosis Systematic review Meta-analysis |
| title | The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis |
| title_full | The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis |
| title_fullStr | The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis |
| title_full_unstemmed | The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis |
| title_short | The prognostic and clinicopathological significance of SLC7A11 in human cancers: a systematic review and meta-analysis |
| title_sort | prognostic and clinicopathological significance of slc7a11 in human cancers a systematic review and meta analysis |
| topic | SLC7A11 Cancer Prognosis Systematic review Meta-analysis |
| url | https://peerj.com/articles/14931.pdf |
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