Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study
Shivering is a common problem during anaesthesia. Ketamine has been used for preventing shivering during anaesthesia. Ondansetron (8 mg) has been recently evaluated for its peri-operative anti-shivering effect in patients undergoing spinal anaethesia. The objective of my study is to compare low dose...
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Society of Turaz Bilim
2018-03-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=267353 |
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| author | Tabish Hussain Khan Karim Afridi Asifa Anwar Mir |
| author_facet | Tabish Hussain Khan Karim Afridi Asifa Anwar Mir |
| author_sort | Tabish Hussain |
| collection | DOAJ |
| description | Shivering is a common problem during anaesthesia. Ketamine has been used for preventing shivering during anaesthesia. Ondansetron (8 mg) has been recently evaluated for its peri-operative anti-shivering effect in patients undergoing spinal anaethesia. The objective of my study is to compare low dose Ondansetron with low dose Ketamine among patients undergoing spinal anesthesia in elective surgery in terms of frequency of shivering. Patients undergoing elective general surgical procedures at Department of Anesthesiology, Holy Family Hospital, Rawalpindi, were inducted in the study. The study design was a randomized control trial and conducted from Jan 2016 to June 2016. Patients were included through a consecutive non-probability sampling. After spinal anaesthesia, patients were randomly assigned to receive Ketamine 0.25 mg/kg (group A) or Ondansetron 4mg (group B) by lottery method. During surgery, shivering was recorded at 10 min interval and recorded in terms of frequency. Out of the total 256 study participants, 128 patients in each group received the study drug (Ondansetron/ Ketamine) before surgery for prevention of shivering. Overall, there were 158 male and 98 female patients. The mean age of study population was 36 ± 11 yrs(range 2140 yrs). Shivering occurred in 11 (4.3%) patients only. There was no significant difference between the gender distributions between the two groups (p=0.16). Patients pre-treated with Ketamine significantly experienced lesser shivering episodes than Ondansetron group (2 (1.6%) vs. 9 (7%), p=0.03). The findings of our study suggest that the prophylactic administration of low dose Ketamine (0.25 mg kg-1) and Ondansetron (4mg) produces anti-shivering effect in patients undergoing spinal anaesthesia Ketamine (0.25 mg/kg) is significantly more effective than Ondansetron (4mg) during spinal anaesthesia. [Med-Science 2018; 7(1.000): 35-38] |
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| language | English |
| last_indexed | 2024-03-08T06:42:10Z |
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| spelling | doaj.art-5f52577e6d234789974f3dc6d6cf8bd62024-02-03T08:36:58ZengSociety of Turaz BilimMedicine Science2147-06342018-03-0171353810.5455/medscience.2017.06.8658267353Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase studyTabish Hussain0Khan Karim AfridiAsifa Anwar MirDepartment of Anesthesia, Critical Care and Pain Medicine, Fauji Foundation Hospital, Kallar Kahar, Pakistan Department of Surgery, Type D Hospital, Katlang, Mardan, PakistanShivering is a common problem during anaesthesia. Ketamine has been used for preventing shivering during anaesthesia. Ondansetron (8 mg) has been recently evaluated for its peri-operative anti-shivering effect in patients undergoing spinal anaethesia. The objective of my study is to compare low dose Ondansetron with low dose Ketamine among patients undergoing spinal anesthesia in elective surgery in terms of frequency of shivering. Patients undergoing elective general surgical procedures at Department of Anesthesiology, Holy Family Hospital, Rawalpindi, were inducted in the study. The study design was a randomized control trial and conducted from Jan 2016 to June 2016. Patients were included through a consecutive non-probability sampling. After spinal anaesthesia, patients were randomly assigned to receive Ketamine 0.25 mg/kg (group A) or Ondansetron 4mg (group B) by lottery method. During surgery, shivering was recorded at 10 min interval and recorded in terms of frequency. Out of the total 256 study participants, 128 patients in each group received the study drug (Ondansetron/ Ketamine) before surgery for prevention of shivering. Overall, there were 158 male and 98 female patients. The mean age of study population was 36 ± 11 yrs(range 2140 yrs). Shivering occurred in 11 (4.3%) patients only. There was no significant difference between the gender distributions between the two groups (p=0.16). Patients pre-treated with Ketamine significantly experienced lesser shivering episodes than Ondansetron group (2 (1.6%) vs. 9 (7%), p=0.03). The findings of our study suggest that the prophylactic administration of low dose Ketamine (0.25 mg kg-1) and Ondansetron (4mg) produces anti-shivering effect in patients undergoing spinal anaesthesia Ketamine (0.25 mg/kg) is significantly more effective than Ondansetron (4mg) during spinal anaesthesia. [Med-Science 2018; 7(1.000): 35-38]http://www.ejmanager.com/fulltextpdf.php?mno=267353Ketamineondansetronshivering |
| spellingShingle | Tabish Hussain Khan Karim Afridi Asifa Anwar Mir Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study Medicine Science Ketamine ondansetron shivering |
| title | Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study |
| title_full | Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study |
| title_fullStr | Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study |
| title_full_unstemmed | Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study |
| title_short | Ondansetron versus Ketamine to control intra-op and post-op shivering caused by subarachnoid block: A comparative phase study |
| title_sort | ondansetron versus ketamine to control intra op and post op shivering caused by subarachnoid block a comparative phase study |
| topic | Ketamine ondansetron shivering |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=267353 |
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