Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis.
A substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections. We conducted a systematic review (PROSPERO, CRD42021229255) with publi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-02-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010073 |
| _version_ | 1811296374612819968 |
|---|---|
| author | Amary Fall Sebastien Kenmoe Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Serges Tchatchouang Marie Amougou Atsama Jacqueline Félicité Yéngué Raoul Kenfack-Momo Alfloditte Flore Feudjio Alex Durand Nka Chris Andre Mbongue Mikangue Jean Bosco Taya-Fokou Jeannette Nina Magoudjou-Pekam Efietngab Atembeh Noura Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Ginette Irma Kame-Ngasse Inès Nyebe Larissa Gertrude Djukouo Landry Kengne Gounmadje Dimitri Tchami Ngongang Martin Gael Oyono Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Gadji Mahamat Cyprien Kengne-Ndé Serge Alain Sadeuh-Mba Ndongo Dia Giuseppina La Rosa Lucy Ndip Richard Njouom |
| author_facet | Amary Fall Sebastien Kenmoe Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Serges Tchatchouang Marie Amougou Atsama Jacqueline Félicité Yéngué Raoul Kenfack-Momo Alfloditte Flore Feudjio Alex Durand Nka Chris Andre Mbongue Mikangue Jean Bosco Taya-Fokou Jeannette Nina Magoudjou-Pekam Efietngab Atembeh Noura Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Ginette Irma Kame-Ngasse Inès Nyebe Larissa Gertrude Djukouo Landry Kengne Gounmadje Dimitri Tchami Ngongang Martin Gael Oyono Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Gadji Mahamat Cyprien Kengne-Ndé Serge Alain Sadeuh-Mba Ndongo Dia Giuseppina La Rosa Lucy Ndip Richard Njouom |
| author_sort | Amary Fall |
| collection | DOAJ |
| description | A substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections. We conducted a systematic review (PROSPERO, CRD42021229255) with published articles on EV-68 infections in PubMed, Embase, Web of Science and Global Index Medicus up to January 2021. We determined prevalences using a model random effect. Of the 4,329 articles retrieved from the databases, 89 studies that met the inclusion criteria were from 39 different countries with apparently healthy individuals and patients with acute respiratory infections, acute flaccid myelitis and asthma-related diseases. The CFR estimate revealed occasional deaths (7/1353) related to EV-D68 infections in patients with severe acute respiratory infections. Analyses showed that the combined prevalence of current and past EV-D68 infections was 4% (95% CI = 3.1-5.0) and 66.3% (95% CI = 40.0-88.2), respectively. The highest prevalences were in hospital outbreaks, developed countries, children under 5, after 2014, and in patients with acute flaccid myelitis and asthma-related diseases. The present study shows sporadic deaths linked to severe respiratory EV-D68 infections. The study also highlights a low prevalence of current EV-D68 infections as opposed to the existence of EV-D68 antibodies in almost all participants of the included studies. These findings therefore highlight the need to implement and/or strengthen continuous surveillance of EV-D68 infections in hospitals and in the community for the anticipation of the response to future epidemics. |
| first_indexed | 2024-04-13T05:48:27Z |
| format | Article |
| id | doaj.art-5f528f91bc15445bba1c4bb6d4eae414 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T05:48:27Z |
| publishDate | 2022-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-5f528f91bc15445bba1c4bb6d4eae4142022-12-22T02:59:53ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-02-01162e001007310.1371/journal.pntd.0010073Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis.Amary FallSebastien KenmoeJean Thierry Ebogo-BeloboDonatien Serge MbagaArnol Bowo-NgandjiJoseph Rodrigue Foe-EssombaSerges TchatchouangMarie Amougou AtsamaJacqueline Félicité YénguéRaoul Kenfack-MomoAlfloditte Flore FeudjioAlex Durand NkaChris Andre Mbongue MikangueJean Bosco Taya-FokouJeannette Nina Magoudjou-PekamEfietngab Atembeh NouraCromwel Zemnou-TepapDowbiss Meta-DjomsiMartin Maïdadi-FoudiGinette Irma Kame-NgasseInès NyebeLarissa Gertrude DjukouoLandry Kengne GounmadjeDimitri Tchami NgongangMartin Gael OyonoCynthia Paola Demeni EmohHervé Raoul TazokongGadji MahamatCyprien Kengne-NdéSerge Alain Sadeuh-MbaNdongo DiaGiuseppina La RosaLucy NdipRichard NjouomA substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections. We conducted a systematic review (PROSPERO, CRD42021229255) with published articles on EV-68 infections in PubMed, Embase, Web of Science and Global Index Medicus up to January 2021. We determined prevalences using a model random effect. Of the 4,329 articles retrieved from the databases, 89 studies that met the inclusion criteria were from 39 different countries with apparently healthy individuals and patients with acute respiratory infections, acute flaccid myelitis and asthma-related diseases. The CFR estimate revealed occasional deaths (7/1353) related to EV-D68 infections in patients with severe acute respiratory infections. Analyses showed that the combined prevalence of current and past EV-D68 infections was 4% (95% CI = 3.1-5.0) and 66.3% (95% CI = 40.0-88.2), respectively. The highest prevalences were in hospital outbreaks, developed countries, children under 5, after 2014, and in patients with acute flaccid myelitis and asthma-related diseases. The present study shows sporadic deaths linked to severe respiratory EV-D68 infections. The study also highlights a low prevalence of current EV-D68 infections as opposed to the existence of EV-D68 antibodies in almost all participants of the included studies. These findings therefore highlight the need to implement and/or strengthen continuous surveillance of EV-D68 infections in hospitals and in the community for the anticipation of the response to future epidemics.https://doi.org/10.1371/journal.pntd.0010073 |
| spellingShingle | Amary Fall Sebastien Kenmoe Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Serges Tchatchouang Marie Amougou Atsama Jacqueline Félicité Yéngué Raoul Kenfack-Momo Alfloditte Flore Feudjio Alex Durand Nka Chris Andre Mbongue Mikangue Jean Bosco Taya-Fokou Jeannette Nina Magoudjou-Pekam Efietngab Atembeh Noura Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maïdadi-Foudi Ginette Irma Kame-Ngasse Inès Nyebe Larissa Gertrude Djukouo Landry Kengne Gounmadje Dimitri Tchami Ngongang Martin Gael Oyono Cynthia Paola Demeni Emoh Hervé Raoul Tazokong Gadji Mahamat Cyprien Kengne-Ndé Serge Alain Sadeuh-Mba Ndongo Dia Giuseppina La Rosa Lucy Ndip Richard Njouom Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. PLoS Neglected Tropical Diseases |
| title | Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. |
| title_full | Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. |
| title_fullStr | Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. |
| title_full_unstemmed | Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. |
| title_short | Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis. |
| title_sort | global prevalence and case fatality rate of enterovirus d68 infections a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pntd.0010073 |
| work_keys_str_mv | AT amaryfall globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT sebastienkenmoe globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT jeanthierryebogobelobo globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT donatiensergembaga globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT arnolbowongandji globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT josephrodriguefoeessomba globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT sergestchatchouang globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT marieamougouatsama globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT jacquelinefeliciteyengue globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT raoulkenfackmomo globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT alfloditteflorefeudjio globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT alexdurandnka globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT chrisandrembonguemikangue globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT jeanboscotayafokou globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT jeannetteninamagoudjoupekam globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT efietngabatembehnoura globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT cromwelzemnoutepap globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT dowbissmetadjomsi globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT martinmaidadifoudi globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT ginetteirmakamengasse globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT inesnyebe globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT larissagertrudedjukouo globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT landrykengnegounmadje globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT dimitritchamingongang globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT martingaeloyono globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT cynthiapaolademeniemoh globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT herveraoultazokong globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT gadjimahamat globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT cyprienkengnende globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT sergealainsadeuhmba globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT ndongodia globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT giuseppinalarosa globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT lucyndip globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis AT richardnjouom globalprevalenceandcasefatalityrateofenterovirusd68infectionsasystematicreviewandmetaanalysis |