Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats
Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the amelior...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2018-03-01
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| Series: | Advanced Pharmaceutical Bulletin |
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| Online Access: | http://apb.tbzmed.ac.ir/PDF/apb-8-141.pdf |
| _version_ | 1828399168227377152 |
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| author | Basiru Olaitan Ajiboye Oluwafemi Adeleke Ojo Oluwatosin Adeyonu Oluwatosin Imiere Babatunji Emmanuel Oyinloye Oluwafemi Ogunmodede |
| author_facet | Basiru Olaitan Ajiboye Oluwafemi Adeleke Ojo Oluwatosin Adeyonu Oluwatosin Imiere Babatunji Emmanuel Oyinloye Oluwafemi Ogunmodede |
| author_sort | Basiru Olaitan Ajiboye |
| collection | DOAJ |
| description | Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats. Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients. |
| first_indexed | 2024-12-10T09:13:26Z |
| format | Article |
| id | doaj.art-5f52e49d843b403d84011f7c90ca0e7b |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-10T09:13:26Z |
| publishDate | 2018-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-5f52e49d843b403d84011f7c90ca0e7b2022-12-22T01:54:56ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082018-03-018114114710.15171/apb.2018.017APB_14651_20160917122234Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic RatsBasiru Olaitan Ajiboye0Oluwafemi Adeleke Ojo1Oluwatosin Adeyonu2Oluwatosin Imiere3Babatunji Emmanuel Oyinloye4Oluwafemi Ogunmodede5Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Department of Chemical Sciences, Biochemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Department of Chemical Sciences, Industrial Chemistry Programme, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats. Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.http://apb.tbzmed.ac.ir/PDF/apb-8-141.pdfArtocarpus heterophyllus stem barkAlloxanSerum lipid profilesHaematological parameters |
| spellingShingle | Basiru Olaitan Ajiboye Oluwafemi Adeleke Ojo Oluwatosin Adeyonu Oluwatosin Imiere Babatunji Emmanuel Oyinloye Oluwafemi Ogunmodede Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats Advanced Pharmaceutical Bulletin Artocarpus heterophyllus stem bark Alloxan Serum lipid profiles Haematological parameters |
| title | Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats |
| title_full | Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats |
| title_fullStr | Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats |
| title_full_unstemmed | Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats |
| title_short | Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats |
| title_sort | ameliorative activity of ethanolic extract of artocarpus heterophyllus stem bark on alloxan induced diabetic rats |
| topic | Artocarpus heterophyllus stem bark Alloxan Serum lipid profiles Haematological parameters |
| url | http://apb.tbzmed.ac.ir/PDF/apb-8-141.pdf |
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