Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis
Abstract Several studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relat...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57394-3 |
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| author | Suk Won Chang Ju Wan Kang |
| author_facet | Suk Won Chang Ju Wan Kang |
| author_sort | Suk Won Chang |
| collection | DOAJ |
| description | Abstract Several studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relationship between microalbuminuria and OSA risk using the STOP-BANG questionnaire in Korean adults. A total of 7478 participants (3289 men and 4189 women) aged over 40 were enrolled in the Korean National Health and Nutrition Examination Survey from 2019 to 2020. STOP-BANG questionnaire to screen OSA was obtained from subjects. The urinary albumin/creatinine ratio (ACR) and proteinuria were measured via a single dipstick to evaluate renal function. The high OSA risk group had a higher mean ACR value than the low OSA risk group (36.8 ± 172.2 vs 17.7 ± 82.5; P < 0.001). The proportion of subjects with values of 30 ≤ ACR < 300 mg/g (11.9% vs 6.1%; P < 0.001) and ACR > 300 mg/g (2.1% vs 0.7%; P < 0.001) was significantly higher in high OSA risk group. Multivariate logistic regression results confirmed that microalbuminuria (OR 1.279, 95% confidence interval (CI) 1.068–1.532, P = 0.008) was significantly correlated with high OSA risk. In addition, significant correlation with high OSA risk was also found in macroalbuminuria (OR 1.684, 95% CI 1.073–2.530, P = 0.022) and proteinuria (OR 1.355, 95% CI 1.030–1.783, P = 0.030). We confirmed a significant correlation between high OSA risk and albuminuria/proteinuria in Korean adults. Therefore, renal function evaluation is required in high OSA risk patients, and OSA diagnosis through PSG test and treatment is necessary. |
| first_indexed | 2024-04-24T19:58:06Z |
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| language | English |
| last_indexed | 2024-04-24T19:58:06Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-5f541a90c86e4d7ba60fe02a9e1b73a72024-03-24T12:15:13ZengNature PortfolioScientific Reports2045-23222024-03-011411710.1038/s41598-024-57394-3Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysisSuk Won Chang0Ju Wan Kang1Department of Otorhinolaryngology, Jeju National University College of MedicineDepartment of Otorhinolaryngology, Yongin Severance Hospital, Yonsei University College of MedicineAbstract Several studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relationship between microalbuminuria and OSA risk using the STOP-BANG questionnaire in Korean adults. A total of 7478 participants (3289 men and 4189 women) aged over 40 were enrolled in the Korean National Health and Nutrition Examination Survey from 2019 to 2020. STOP-BANG questionnaire to screen OSA was obtained from subjects. The urinary albumin/creatinine ratio (ACR) and proteinuria were measured via a single dipstick to evaluate renal function. The high OSA risk group had a higher mean ACR value than the low OSA risk group (36.8 ± 172.2 vs 17.7 ± 82.5; P < 0.001). The proportion of subjects with values of 30 ≤ ACR < 300 mg/g (11.9% vs 6.1%; P < 0.001) and ACR > 300 mg/g (2.1% vs 0.7%; P < 0.001) was significantly higher in high OSA risk group. Multivariate logistic regression results confirmed that microalbuminuria (OR 1.279, 95% confidence interval (CI) 1.068–1.532, P = 0.008) was significantly correlated with high OSA risk. In addition, significant correlation with high OSA risk was also found in macroalbuminuria (OR 1.684, 95% CI 1.073–2.530, P = 0.022) and proteinuria (OR 1.355, 95% CI 1.030–1.783, P = 0.030). We confirmed a significant correlation between high OSA risk and albuminuria/proteinuria in Korean adults. Therefore, renal function evaluation is required in high OSA risk patients, and OSA diagnosis through PSG test and treatment is necessary.https://doi.org/10.1038/s41598-024-57394-3AlbuminuriaObstructive sleep apneaAlbumin/creatinine ratioKorean |
| spellingShingle | Suk Won Chang Ju Wan Kang Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis Scientific Reports Albuminuria Obstructive sleep apnea Albumin/creatinine ratio Korean |
| title | Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis |
| title_full | Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis |
| title_fullStr | Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis |
| title_full_unstemmed | Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis |
| title_short | Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis |
| title_sort | increasing obstructive sleep apnea risk is associated with albuminuria in korean adults cross sectional analysis |
| topic | Albuminuria Obstructive sleep apnea Albumin/creatinine ratio Korean |
| url | https://doi.org/10.1038/s41598-024-57394-3 |
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