Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway

Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway

Abstract Background Tribbles pseudokinase 3 (TRIB3) protein is a pseudokinase which plays an important role in cellular stress, metabolism, and tumor progression. However, the expression and function of TRIB3 in ovarian cancer is unknown. Methods TRIB3 expression was detected by immunohistochemistry...

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Bibliographic Details
Main Authors: Shuang Wang, Caixia Wang, Xiao Li, Yuexin Hu, Rui Gou, Qian Guo, Xin Nie, Juanjuan Liu, Liancheng Zhu, Bei Lin
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cancer Cell International
Subjects:
TRIB3
Ovarian cancer
Prognosis
MEK/ERK
EMT
Online Access:http://link.springer.com/article/10.1186/s12935-020-01509-z

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