Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms

Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms

Klebsiella pneumoniae produces capsular polysaccharides that are a crucial virulence factor protecting bacteria against innate response mechanisms of the infected host. Simultaneously, those capsules are targeted by specific bacteriophages equipped with virion-associated depolymerases able to recogn...

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Bibliographic Details
Main Authors: Grazyna Majkowska-Skrobek, Agnieszka Latka, Rita Berisio, Flavia Squeglia, Barbara Maciejewska, Yves Briers, Zuzanna Drulis-Kawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
bacteriophage
Klebsiella sp.
capsule
polysaccharide depolymerase
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02517/full

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