Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.

Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.

Genetic variants in the asialoglycoprotein receptor 1 (ASGR1) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs us...

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Bibliographic Details
Main Authors: Baocai Xie, Xiaochen Shi, Yan Li, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A Mitchell, Dengke Pan, Mingzhou Li, Jiangwei Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009891

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https://doi.org/10.1371/journal.pgen.1009891

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