The Mechanism for siRNA Transmembrane Assisted by PMAL

The capacity of silencing genes makes small interfering RNA (siRNA) appealing for curing fatal diseases. However, the naked siRNA is vulnerable to and degraded by endogenous enzymes and is too large and too negatively charged to cross cellular membranes. An effective siRNA carrier, PMAL (poly(maleic...

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Hlavní autoři: Yanfei Lu, Jipeng Li, Nan Su, Diannan Lu
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2018-06-01
Edice:Molecules
Témata:
On-line přístup:http://www.mdpi.com/1420-3049/23/7/1586