Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice
Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucid...
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MDPI AG
2019-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/11/5/1045 |
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| author | Atsushi Masuda Yusuke Seino Masatoshi Murase Shihomi Hidaka Megumi Shibata Takeshi Takayanagi Yoshihisa Sugimura Yoshitaka Hayashi Atsushi Suzuki |
| author_facet | Atsushi Masuda Yusuke Seino Masatoshi Murase Shihomi Hidaka Megumi Shibata Takeshi Takayanagi Yoshihisa Sugimura Yoshitaka Hayashi Atsushi Suzuki |
| author_sort | Atsushi Masuda |
| collection | DOAJ |
| description | Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding. |
| first_indexed | 2024-04-13T02:54:59Z |
| format | Article |
| id | doaj.art-5f5ac709a22c46da92513caa4d55dac2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-13T02:54:59Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5f5ac709a22c46da92513caa4d55dac22022-12-22T03:05:41ZengMDPI AGNutrients2072-66432019-05-01115104510.3390/nu11051045nu11051045Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in MiceAtsushi Masuda0Yusuke Seino1Masatoshi Murase2Shihomi Hidaka3Megumi Shibata4Takeshi Takayanagi5Yoshihisa Sugimura6Yoshitaka Hayashi7Atsushi Suzuki8Department of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartments of Endocrinology and Diabetes, Toyota Memorial Hospital, Toyota 471-8513, JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanDepartment of Endocrinology, Research Institute of Environmental Medicine, Nagoya University, Nagoya 467-8601 JapanDepartment of Endocrinology and Metabolism, Fujita Health University, Graduate School of Medicine, Toyoake 470-1192, JapanLong-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.https://www.mdpi.com/2072-6643/11/5/1045carbohydrateβ-cell massislet numberinsulindietary intervention |
| spellingShingle | Atsushi Masuda Yusuke Seino Masatoshi Murase Shihomi Hidaka Megumi Shibata Takeshi Takayanagi Yoshihisa Sugimura Yoshitaka Hayashi Atsushi Suzuki Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice Nutrients carbohydrate β-cell mass islet number insulin dietary intervention |
| title | Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice |
| title_full | Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice |
| title_fullStr | Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice |
| title_full_unstemmed | Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice |
| title_short | Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in β-cell Mass Independent of Body Weight Gain in Mice |
| title_sort | short term high starch low protein diet induces reversible increase in β cell mass independent of body weight gain in mice |
| topic | carbohydrate β-cell mass islet number insulin dietary intervention |
| url | https://www.mdpi.com/2072-6643/11/5/1045 |
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