Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies.
<h4>Background</h4>Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension devel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114259&type=printable |
| _version_ | 1826587352222400512 |
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| author | Ji Wang Tianqiang Qin Jianrong Chen Yulin Li Ling Wang He Huang Jing Li |
| author_facet | Ji Wang Tianqiang Qin Jianrong Chen Yulin Li Ling Wang He Huang Jing Li |
| author_sort | Ji Wang |
| collection | DOAJ |
| description | <h4>Background</h4>Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension development.<h4>Methods</h4>We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and reference lists of retrieved studies to identify cohort studies and nested case-control studies with uric acid levels as exposure and incident hypertension as outcome variables. Two reviewers independently extracted data and assessed study quality using Newcastle-Ottawa Scale. Extracted information included study design, population, definition of hyperuricemia and hypertension, number of incident hypertension, effect sizes, and adjusted confounders. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for the association between hyperuricemia and risk of hypertension were calculated using a random-effects model.<h4>Results</h4>We included 25 studies with 97,824 participants assessing the association between uric acid and incident hypertension in our meta-analysis. The quality of included studies is moderate to high. Random-effects meta-analysis showed that hyperuricemia was associated with a higher risk of incident hypertension, regardless of whether the effect size was adjusted or not, whether the data were categorical or continuous as 1 SD/1 mg/dl increase in uric acid level (unadjusted: RR = 1.73, 95% CI 1.46∼2.06 for categorical data, RR = 1.22, 95% CI 1.03∼1.45 for a 1 SD increase; adjusted: RR = 1.48, 95% CI 1.33∼1.65 for categorical data, RR = 1.15, 95% CI 1.06∼1.26 for a 1 mg/dl increase), and the risk is consistent in subgroup analyses and have a dose-response relationship.<h4>Conclusions</h4>Hyperuricemia may modestly increase the risk of hypertension incidence, consistent with a dose-response relationship. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T16:24:04Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-5f5c9478b7624b9691ecb480fe18321a2025-02-22T05:32:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11425910.1371/journal.pone.0114259Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies.Ji WangTianqiang QinJianrong ChenYulin LiLing WangHe HuangJing Li<h4>Background</h4>Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension development.<h4>Methods</h4>We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and reference lists of retrieved studies to identify cohort studies and nested case-control studies with uric acid levels as exposure and incident hypertension as outcome variables. Two reviewers independently extracted data and assessed study quality using Newcastle-Ottawa Scale. Extracted information included study design, population, definition of hyperuricemia and hypertension, number of incident hypertension, effect sizes, and adjusted confounders. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for the association between hyperuricemia and risk of hypertension were calculated using a random-effects model.<h4>Results</h4>We included 25 studies with 97,824 participants assessing the association between uric acid and incident hypertension in our meta-analysis. The quality of included studies is moderate to high. Random-effects meta-analysis showed that hyperuricemia was associated with a higher risk of incident hypertension, regardless of whether the effect size was adjusted or not, whether the data were categorical or continuous as 1 SD/1 mg/dl increase in uric acid level (unadjusted: RR = 1.73, 95% CI 1.46∼2.06 for categorical data, RR = 1.22, 95% CI 1.03∼1.45 for a 1 SD increase; adjusted: RR = 1.48, 95% CI 1.33∼1.65 for categorical data, RR = 1.15, 95% CI 1.06∼1.26 for a 1 mg/dl increase), and the risk is consistent in subgroup analyses and have a dose-response relationship.<h4>Conclusions</h4>Hyperuricemia may modestly increase the risk of hypertension incidence, consistent with a dose-response relationship.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114259&type=printable |
| spellingShingle | Ji Wang Tianqiang Qin Jianrong Chen Yulin Li Ling Wang He Huang Jing Li Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS ONE |
| title | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. |
| title_full | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. |
| title_fullStr | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. |
| title_full_unstemmed | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. |
| title_short | Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. |
| title_sort | hyperuricemia and risk of incident hypertension a systematic review and meta analysis of observational studies |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114259&type=printable |
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