Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze
Abstract Objective Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more side effects, making therapy more difficult. Different medicinal plants are...
| Những tác giả chính: | , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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BMC
2022-10-01
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| Loạt: | BMC Research Notes |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://doi.org/10.1186/s13104-022-06219-5 |
| _version_ | 1828161089628536832 |
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| author | Sadia Afrin Ahmed Hossain Shelina Begum |
| author_facet | Sadia Afrin Ahmed Hossain Shelina Begum |
| author_sort | Sadia Afrin |
| collection | DOAJ |
| description | Abstract Objective Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more side effects, making therapy more difficult. Different medicinal plants are now being highlighted because of their valuable applications and low risk of adverse effects. Moringa oleifera is one of these plants that has gained much attention due to its diverse biological functions. The study aimed to determine the effects of Moringa oleifera on working memory in memory-impaired Wistar rats. Results For this experimental study, 30 male Wistar rats having 150–250 g bodyweight were divided equally into three groups: Group-I/normal memory group (treated with oral normal saline 5 ml/kg body weight), Group-II/memory-impaired group (induced by intraperitoneal ketamine 15 mg/kg body weight), and Group-III/experimental group (treated with oral Moringa oleifera 200 mg/kg bodyweight and intraperitoneal ketamine 15 mg/kg body weight). The experimental group showed significantly fewer working memory errors than the memory-impaired group. The experimental group also provides the lowest variability of WMEs among groups. Thus, the study concludes that M. oleifera can prevent ketamine-induced memory impairment in Wistar rats. |
| first_indexed | 2024-04-12T00:33:06Z |
| format | Article |
| id | doaj.art-5f5ccc40b9a847bc8e9cc0a3a103631c |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-12T00:33:06Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-5f5ccc40b9a847bc8e9cc0a3a103631c2022-12-22T03:55:17ZengBMCBMC Research Notes1756-05002022-10-011511610.1186/s13104-022-06219-5Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm mazeSadia Afrin0Ahmed Hossain1Shelina Begum2Department of Physiology, Marks Medical College and HospitalCollege of Health Sciences, University of SharjahDepartment of Physiology, Bangabandhu Sheikh Mujib Medical UniversityAbstract Objective Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more side effects, making therapy more difficult. Different medicinal plants are now being highlighted because of their valuable applications and low risk of adverse effects. Moringa oleifera is one of these plants that has gained much attention due to its diverse biological functions. The study aimed to determine the effects of Moringa oleifera on working memory in memory-impaired Wistar rats. Results For this experimental study, 30 male Wistar rats having 150–250 g bodyweight were divided equally into three groups: Group-I/normal memory group (treated with oral normal saline 5 ml/kg body weight), Group-II/memory-impaired group (induced by intraperitoneal ketamine 15 mg/kg body weight), and Group-III/experimental group (treated with oral Moringa oleifera 200 mg/kg bodyweight and intraperitoneal ketamine 15 mg/kg body weight). The experimental group showed significantly fewer working memory errors than the memory-impaired group. The experimental group also provides the lowest variability of WMEs among groups. Thus, the study concludes that M. oleifera can prevent ketamine-induced memory impairment in Wistar rats.https://doi.org/10.1186/s13104-022-06219-5MemoryMoringa oleiferaWorking memoryRadial arm maze testNMDA receptor |
| spellingShingle | Sadia Afrin Ahmed Hossain Shelina Begum Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze BMC Research Notes Memory Moringa oleifera Working memory Radial arm maze test NMDA receptor |
| title | Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze |
| title_full | Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze |
| title_fullStr | Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze |
| title_full_unstemmed | Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze |
| title_short | Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze |
| title_sort | effects of moringa oleifera on working memory an experimental study with memory impaired wistar rats tested in radial arm maze |
| topic | Memory Moringa oleifera Working memory Radial arm maze test NMDA receptor |
| url | https://doi.org/10.1186/s13104-022-06219-5 |
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