HOX Protein Activity Regulation by Cellular Localization
While the functions of <i>HOX</i> genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented. In particular, the mechanisms involved in regulating the activity of HOX proteins have been po...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/9/4/56 |
| _version_ | 1797503374243921920 |
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| author | Laure Bridoux Françoise Gofflot René Rezsohazy |
| author_facet | Laure Bridoux Françoise Gofflot René Rezsohazy |
| author_sort | Laure Bridoux |
| collection | DOAJ |
| description | While the functions of <i>HOX</i> genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented. In particular, the mechanisms involved in regulating the activity of HOX proteins have been poorly investigated. Nonetheless, based on data available from other well-characterized transcription factors, it can be assumed that HOX protein activity must be finely tuned in a cell-type-specific manner and in response to defined environmental cues. Indeed, records in protein–protein interaction databases or entries in post-translational modification registries clearly support that HOX proteins are the targets of multiple layers of regulation at the protein level. In this context, we review here what has been reported and what can be inferred about how the activities of HOX proteins are regulated by their intracellular distribution. |
| first_indexed | 2024-03-10T03:49:42Z |
| format | Article |
| id | doaj.art-5f5d5f80f4b8483d8fe0f0d9a5a05b89 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T03:49:42Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-5f5d5f80f4b8483d8fe0f0d9a5a05b892023-11-23T08:59:43ZengMDPI AGJournal of Developmental Biology2221-37592021-12-01945610.3390/jdb9040056HOX Protein Activity Regulation by Cellular LocalizationLaure Bridoux0Françoise Gofflot1René Rezsohazy2Louvain Institute of Biomolecular Science and Technology, UCLouvain, B-1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, B-1348 Louvain-la-Neuve, BelgiumLouvain Institute of Biomolecular Science and Technology, UCLouvain, B-1348 Louvain-la-Neuve, BelgiumWhile the functions of <i>HOX</i> genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented. In particular, the mechanisms involved in regulating the activity of HOX proteins have been poorly investigated. Nonetheless, based on data available from other well-characterized transcription factors, it can be assumed that HOX protein activity must be finely tuned in a cell-type-specific manner and in response to defined environmental cues. Indeed, records in protein–protein interaction databases or entries in post-translational modification registries clearly support that HOX proteins are the targets of multiple layers of regulation at the protein level. In this context, we review here what has been reported and what can be inferred about how the activities of HOX proteins are regulated by their intracellular distribution.https://www.mdpi.com/2221-3759/9/4/56HOX proteinscellular localizationkaryopherinsactivity regulation |
| spellingShingle | Laure Bridoux Françoise Gofflot René Rezsohazy HOX Protein Activity Regulation by Cellular Localization Journal of Developmental Biology HOX proteins cellular localization karyopherins activity regulation |
| title | HOX Protein Activity Regulation by Cellular Localization |
| title_full | HOX Protein Activity Regulation by Cellular Localization |
| title_fullStr | HOX Protein Activity Regulation by Cellular Localization |
| title_full_unstemmed | HOX Protein Activity Regulation by Cellular Localization |
| title_short | HOX Protein Activity Regulation by Cellular Localization |
| title_sort | hox protein activity regulation by cellular localization |
| topic | HOX proteins cellular localization karyopherins activity regulation |
| url | https://www.mdpi.com/2221-3759/9/4/56 |
| work_keys_str_mv | AT laurebridoux hoxproteinactivityregulationbycellularlocalization AT francoisegofflot hoxproteinactivityregulationbycellularlocalization AT renerezsohazy hoxproteinactivityregulationbycellularlocalization |