Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis
Abstract This case report describes the clinical presentation, the necropsy findings, and genetic results of a 13‐year‐old Warmblood mare presented with colic and a bilaterally loud, holosystolic murmur. Echocardiographic examination revealed the presence of a thoracic aortic aneurysm, an aortic pse...
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| Format: | Article |
| Language: | English |
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Wiley
2020-09-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.15893 |
| _version_ | 1818188508145123328 |
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| author | Veronique Saey Annelies Decloedt Mario Van Poucke Luc Peelman Gunther vanLoon Katrien Vanderperren Richard Ducatelle Koen Chiers |
| author_facet | Veronique Saey Annelies Decloedt Mario Van Poucke Luc Peelman Gunther vanLoon Katrien Vanderperren Richard Ducatelle Koen Chiers |
| author_sort | Veronique Saey |
| collection | DOAJ |
| description | Abstract This case report describes the clinical presentation, the necropsy findings, and genetic results of a 13‐year‐old Warmblood mare presented with colic and a bilaterally loud, holosystolic murmur. Echocardiographic examination revealed the presence of a thoracic aortic aneurysm, an aortic pseudoaneurysm, a periaortic hematoma (circumferential cuffing by perivascular hemorrhage), and aortopulmonary fistulation. A supravalvular aortic stenosis (SVAS) was visible during echocardiography. Necropsy confirmed that the thoracic aortic aneurysm had ruptured and connected to the pseudoaneurysm, which fistulated into the pulmonary artery. Histologically, the aneurysm wall revealed chronic lesions such as fibrosis, mucin depositions, mineralizations, and elastin fragmentation. The mid abdominal aorta showed lesions suggestive of a systemic elastin arteriopathy. Molecular analysis, however, could not attribute this disease to a variant in the elastin gene, the most common causative gene for SVAS. To the authors' knowledge, this case report describes a case of aortopulmonary fistulation in a Warmblood horse associated with the presence of SVAS and an aortic aneurysm. |
| first_indexed | 2024-12-11T23:28:02Z |
| format | Article |
| id | doaj.art-5f5fc12ee70448dfa6e0b04bfc55a6be |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-11T23:28:02Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-5f5fc12ee70448dfa6e0b04bfc55a6be2022-12-22T00:46:07ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-09-013452152215710.1111/jvim.15893Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosisVeronique Saey0Annelies Decloedt1Mario Van Poucke2Luc Peelman3Gunther vanLoon4Katrien Vanderperren5Richard Ducatelle6Koen Chiers7Department of Veterinary Pathology, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Veterinary Pathology, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumDepartment of Veterinary Pathology, Faculty of Veterinary Medicine Ghent University Merelbeke BelgiumAbstract This case report describes the clinical presentation, the necropsy findings, and genetic results of a 13‐year‐old Warmblood mare presented with colic and a bilaterally loud, holosystolic murmur. Echocardiographic examination revealed the presence of a thoracic aortic aneurysm, an aortic pseudoaneurysm, a periaortic hematoma (circumferential cuffing by perivascular hemorrhage), and aortopulmonary fistulation. A supravalvular aortic stenosis (SVAS) was visible during echocardiography. Necropsy confirmed that the thoracic aortic aneurysm had ruptured and connected to the pseudoaneurysm, which fistulated into the pulmonary artery. Histologically, the aneurysm wall revealed chronic lesions such as fibrosis, mucin depositions, mineralizations, and elastin fragmentation. The mid abdominal aorta showed lesions suggestive of a systemic elastin arteriopathy. Molecular analysis, however, could not attribute this disease to a variant in the elastin gene, the most common causative gene for SVAS. To the authors' knowledge, this case report describes a case of aortopulmonary fistulation in a Warmblood horse associated with the presence of SVAS and an aortic aneurysm.https://doi.org/10.1111/jvim.15893aortic diseaseelastin geneequinepseudoaneurysm |
| spellingShingle | Veronique Saey Annelies Decloedt Mario Van Poucke Luc Peelman Gunther vanLoon Katrien Vanderperren Richard Ducatelle Koen Chiers Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis Journal of Veterinary Internal Medicine aortic disease elastin gene equine pseudoaneurysm |
| title | Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| title_full | Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| title_fullStr | Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| title_full_unstemmed | Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| title_short | Aortopulmonary fistula in a Warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| title_sort | aortopulmonary fistula in a warmblood mare associated with an aortic aneurysm and supravalvular aortic stenosis |
| topic | aortic disease elastin gene equine pseudoaneurysm |
| url | https://doi.org/10.1111/jvim.15893 |
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