Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis
Botulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/8/7/201 |
| _version_ | 1797999543881564160 |
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| author | Bin Chiu Huai-Ching Tai Shiu-Dong Chung Lori A. Birder |
| author_facet | Bin Chiu Huai-Ching Tai Shiu-Dong Chung Lori A. Birder |
| author_sort | Bin Chiu |
| collection | DOAJ |
| description | Botulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/interstitial cystitis (BPS/IC). However, in the field of urology, chronic bladder or pelvic pain is often difficult to eradicate by oral medications or bladder instillation therapy. We are looking for new treatment modality to improve bladder pain or associated urinary symptoms such as frequency and urgency for patients with BPS/IC. Recent studies investigating the mechanism of the antinociceptive effects of BoNT A suggest that it can inhibit the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. In this review, we will examine the evidence supporting the use of BoNTs in bladder pain from basic science models and review the clinical studies on therapeutic applications of BoNT for BPS/IC. |
| first_indexed | 2024-04-11T11:06:21Z |
| format | Article |
| id | doaj.art-5f622b25c0d2451aadb8316555f85763 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T11:06:21Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-5f622b25c0d2451aadb8316555f857632022-12-22T04:28:21ZengMDPI AGToxins2072-66512016-07-018720110.3390/toxins8070201toxins8070201Botulinum Toxin A for Bladder Pain Syndrome/Interstitial CystitisBin Chiu0Huai-Ching Tai1Shiu-Dong Chung2Lori A. Birder3Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, New Taipei City 220, TaiwanDepartment of Urology, National Taiwan University Hospital, Taipei 100, TaiwanDivision of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, New Taipei City 220, TaiwanDepartment of Medicine-Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USABotulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/interstitial cystitis (BPS/IC). However, in the field of urology, chronic bladder or pelvic pain is often difficult to eradicate by oral medications or bladder instillation therapy. We are looking for new treatment modality to improve bladder pain or associated urinary symptoms such as frequency and urgency for patients with BPS/IC. Recent studies investigating the mechanism of the antinociceptive effects of BoNT A suggest that it can inhibit the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. In this review, we will examine the evidence supporting the use of BoNTs in bladder pain from basic science models and review the clinical studies on therapeutic applications of BoNT for BPS/IC.http://www.mdpi.com/2072-6651/8/7/201cystitisbotulinum toxin Ainterstitial cystitisintravesical injection |
| spellingShingle | Bin Chiu Huai-Ching Tai Shiu-Dong Chung Lori A. Birder Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis Toxins cystitis botulinum toxin A interstitial cystitis intravesical injection |
| title | Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis |
| title_full | Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis |
| title_fullStr | Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis |
| title_full_unstemmed | Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis |
| title_short | Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis |
| title_sort | botulinum toxin a for bladder pain syndrome interstitial cystitis |
| topic | cystitis botulinum toxin A interstitial cystitis intravesical injection |
| url | http://www.mdpi.com/2072-6651/8/7/201 |
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