SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models.
The remarkable advance in sequencing technology and the rising interest in medical and environmental microbiology, biotechnology, and synthetic biology resulted in a deluge of published microbial genomes. Yet, genome annotation, comparison, and modeling remain a major bottleneck to the translation o...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3480482?pdf=render |
| _version_ | 1819268107560026112 |
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| author | Ramy K Aziz Scott Devoid Terrence Disz Robert A Edwards Christopher S Henry Gary J Olsen Robert Olson Ross Overbeek Bruce Parrello Gordon D Pusch Rick L Stevens Veronika Vonstein Fangfang Xia |
| author_facet | Ramy K Aziz Scott Devoid Terrence Disz Robert A Edwards Christopher S Henry Gary J Olsen Robert Olson Ross Overbeek Bruce Parrello Gordon D Pusch Rick L Stevens Veronika Vonstein Fangfang Xia |
| author_sort | Ramy K Aziz |
| collection | DOAJ |
| description | The remarkable advance in sequencing technology and the rising interest in medical and environmental microbiology, biotechnology, and synthetic biology resulted in a deluge of published microbial genomes. Yet, genome annotation, comparison, and modeling remain a major bottleneck to the translation of sequence information into biological knowledge, hence computational analysis tools are continuously being developed for rapid genome annotation and interpretation. Among the earliest, most comprehensive resources for prokaryotic genome analysis, the SEED project, initiated in 2003 as an integration of genomic data and analysis tools, now contains >5,000 complete genomes, a constantly updated set of curated annotations embodied in a large and growing collection of encoded subsystems, a derived set of protein families, and hundreds of genome-scale metabolic models. Until recently, however, maintaining current copies of the SEED code and data at remote locations has been a pressing issue. To allow high-performance remote access to the SEED database, we developed the SEED Servers (http://www.theseed.org/servers): four network-based servers intended to expose the data in the underlying relational database, support basic annotation services, offer programmatic access to the capabilities of the RAST annotation server, and provide access to a growing collection of metabolic models that support flux balance analysis. The SEED servers offer open access to regularly updated data, the ability to annotate prokaryotic genomes, the ability to create metabolic reconstructions and detailed models of metabolism, and access to hundreds of existing metabolic models. This work offers and supports a framework upon which other groups can build independent research efforts. Large integrations of genomic data represent one of the major intellectual resources driving research in biology, and programmatic access to the SEED data will provide significant utility to a broad collection of potential users. |
| first_indexed | 2024-12-23T21:27:48Z |
| format | Article |
| id | doaj.art-5f62a117c55546dab4d00f676c98ad3a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T21:27:48Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5f62a117c55546dab4d00f676c98ad3a2022-12-21T17:30:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4805310.1371/journal.pone.0048053SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models.Ramy K AzizScott DevoidTerrence DiszRobert A EdwardsChristopher S HenryGary J OlsenRobert OlsonRoss OverbeekBruce ParrelloGordon D PuschRick L StevensVeronika VonsteinFangfang XiaThe remarkable advance in sequencing technology and the rising interest in medical and environmental microbiology, biotechnology, and synthetic biology resulted in a deluge of published microbial genomes. Yet, genome annotation, comparison, and modeling remain a major bottleneck to the translation of sequence information into biological knowledge, hence computational analysis tools are continuously being developed for rapid genome annotation and interpretation. Among the earliest, most comprehensive resources for prokaryotic genome analysis, the SEED project, initiated in 2003 as an integration of genomic data and analysis tools, now contains >5,000 complete genomes, a constantly updated set of curated annotations embodied in a large and growing collection of encoded subsystems, a derived set of protein families, and hundreds of genome-scale metabolic models. Until recently, however, maintaining current copies of the SEED code and data at remote locations has been a pressing issue. To allow high-performance remote access to the SEED database, we developed the SEED Servers (http://www.theseed.org/servers): four network-based servers intended to expose the data in the underlying relational database, support basic annotation services, offer programmatic access to the capabilities of the RAST annotation server, and provide access to a growing collection of metabolic models that support flux balance analysis. The SEED servers offer open access to regularly updated data, the ability to annotate prokaryotic genomes, the ability to create metabolic reconstructions and detailed models of metabolism, and access to hundreds of existing metabolic models. This work offers and supports a framework upon which other groups can build independent research efforts. Large integrations of genomic data represent one of the major intellectual resources driving research in biology, and programmatic access to the SEED data will provide significant utility to a broad collection of potential users.http://europepmc.org/articles/PMC3480482?pdf=render |
| spellingShingle | Ramy K Aziz Scott Devoid Terrence Disz Robert A Edwards Christopher S Henry Gary J Olsen Robert Olson Ross Overbeek Bruce Parrello Gordon D Pusch Rick L Stevens Veronika Vonstein Fangfang Xia SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. PLoS ONE |
| title | SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. |
| title_full | SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. |
| title_fullStr | SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. |
| title_full_unstemmed | SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. |
| title_short | SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. |
| title_sort | seed servers high performance access to the seed genomes annotations and metabolic models |
| url | http://europepmc.org/articles/PMC3480482?pdf=render |
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