Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results
Treatment of a wide variety of defects in the oral and maxillofacial regions requires the use of innovative approaches to achieve best outcomes. One of the promising directions is the use of gene-activated materials (GAMs) that represent a combination of tissue engineering and gene therapy. This app...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/22/16250 |
| _version_ | 1797458980811833344 |
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| author | Olga Krasilnikova Anna Yakimova Sergey Ivanov Dmitri Atiakshin Andrey A. Kostin Dmitry Sosin Peter Shegay Andrey D. Kaprin Ilya Klabukov |
| author_facet | Olga Krasilnikova Anna Yakimova Sergey Ivanov Dmitri Atiakshin Andrey A. Kostin Dmitry Sosin Peter Shegay Andrey D. Kaprin Ilya Klabukov |
| author_sort | Olga Krasilnikova |
| collection | DOAJ |
| description | Treatment of a wide variety of defects in the oral and maxillofacial regions requires the use of innovative approaches to achieve best outcomes. One of the promising directions is the use of gene-activated materials (GAMs) that represent a combination of tissue engineering and gene therapy. This approach implies that biocompatible materials will be enriched with gene-carrying vectors and implanted into the defect site resulting in transfection of the recipient’s cells and secretion of encoded therapeutic protein in situ. GAMs may be presented in various designs depending on the type of material, encoded protein, vector, and way of connecting the vector and the material. Thus, it is possible to choose the most suitable GAM design for the treatment of a particular pathology. The use of plasmids for delivery of therapeutic genes is of particular interest. In the present review, we aimed to delineate the principle of work and various designs of plasmid-based GAMs and to highlight results of experimental and clinical studies devoted to the treatment of periodontitis, jaw bone defects, teeth avulsion, and other pathologies in the oral and maxillofacial regions. |
| first_indexed | 2024-03-09T16:45:53Z |
| format | Article |
| id | doaj.art-5f64763414594988854b2c5932e4ae61 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:45:53Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5f64763414594988854b2c5932e4ae612023-11-24T14:46:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124221625010.3390/ijms242216250Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study ResultsOlga Krasilnikova0Anna Yakimova1Sergey Ivanov2Dmitri Atiakshin3Andrey A. Kostin4Dmitry Sosin5Peter Shegay6Andrey D. Kaprin7Ilya Klabukov8National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, RussiaA. Tsyb Medical Radiological Research Centre—Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Zhukov St. 10, 249031 Obninsk, RussiaA. Tsyb Medical Radiological Research Centre—Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Zhukov St. 10, 249031 Obninsk, RussiaScientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis, Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaDepartment of Urology and Operative Nephrology, Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklay St. 6, 117198 Moscow, RussiaCentre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, 119121 Moscow, RussiaNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, RussiaNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, RussiaNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, RussiaTreatment of a wide variety of defects in the oral and maxillofacial regions requires the use of innovative approaches to achieve best outcomes. One of the promising directions is the use of gene-activated materials (GAMs) that represent a combination of tissue engineering and gene therapy. This approach implies that biocompatible materials will be enriched with gene-carrying vectors and implanted into the defect site resulting in transfection of the recipient’s cells and secretion of encoded therapeutic protein in situ. GAMs may be presented in various designs depending on the type of material, encoded protein, vector, and way of connecting the vector and the material. Thus, it is possible to choose the most suitable GAM design for the treatment of a particular pathology. The use of plasmids for delivery of therapeutic genes is of particular interest. In the present review, we aimed to delineate the principle of work and various designs of plasmid-based GAMs and to highlight results of experimental and clinical studies devoted to the treatment of periodontitis, jaw bone defects, teeth avulsion, and other pathologies in the oral and maxillofacial regions.https://www.mdpi.com/1422-0067/24/22/16250dentistrygene activationgene therapyperiodontitisregenerative medicinetissue engineering |
| spellingShingle | Olga Krasilnikova Anna Yakimova Sergey Ivanov Dmitri Atiakshin Andrey A. Kostin Dmitry Sosin Peter Shegay Andrey D. Kaprin Ilya Klabukov Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results International Journal of Molecular Sciences dentistry gene activation gene therapy periodontitis regenerative medicine tissue engineering |
| title | Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results |
| title_full | Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results |
| title_fullStr | Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results |
| title_full_unstemmed | Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results |
| title_short | Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results |
| title_sort | gene activated materials in regenerative dentistry narrative review of technology and study results |
| topic | dentistry gene activation gene therapy periodontitis regenerative medicine tissue engineering |
| url | https://www.mdpi.com/1422-0067/24/22/16250 |
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