Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinica...

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Bibliographic Details
Main Authors: S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, John J. Tentler, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, Wells A. Messersmith, Aik Choon eTan, S. Gail eEckhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
PIK3CA
KRAS mutation
trametinib
alisertib
MEK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00120/full

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