Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors
Abstract Biodegradable piezoelectric force sensors can be used as implantable medical devices for monitoring physiological pressures of impaired organs or providing essential stimuli for drug delivery and tissue regeneration without the need of additional invasive removal surgery or battery power. H...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202207269 |
| _version_ | 1797846484373209088 |
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| author | Yuanqi Cheng Juan Xu Lan Li Pingqiang Cai Ying Li Qing Jiang Wei Wang Yi Cao Bin Xue |
| author_facet | Yuanqi Cheng Juan Xu Lan Li Pingqiang Cai Ying Li Qing Jiang Wei Wang Yi Cao Bin Xue |
| author_sort | Yuanqi Cheng |
| collection | DOAJ |
| description | Abstract Biodegradable piezoelectric force sensors can be used as implantable medical devices for monitoring physiological pressures of impaired organs or providing essential stimuli for drug delivery and tissue regeneration without the need of additional invasive removal surgery or battery power. However, traditional piezoelectric materials, such as inorganic ceramics and organic polymers, show unsatisfactory degradability, and cytotoxicity. Amino acid crystals are biocompatible and exhibit outstanding piezoelectric properties, but their small crystal size makes it difficult to align the crystals for practical applications. Here, a mechanical‐annealing strategy is reported for engineering all‐organic biodegradable piezoelectric force sensors using natural amino acid crystals as piezoelectric materials. It is shown that the piezoelectric constant of the mechanical‐annealed crystals can reach 12 times that of the single crystal powders. Moreover, mechanical annealing results in flat and smooth surfaces, thus improving the contact of the crystal films with the electrodes and leading to high output voltages of the devices. The packaged force sensors can be used to monitor dynamic motions, including muscle contraction and lung respiration, in vivo for 4 weeks and then gradually degrade without causing obvious inflammation or systemic toxicity. This work provides a way to engineer all‐organic and biodegradable force sensors for potential clinical applications. |
| first_indexed | 2024-04-09T17:56:46Z |
| format | Article |
| id | doaj.art-5f68473db14e43d58610d4a17e851b6e |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T17:56:46Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-5f68473db14e43d58610d4a17e851b6e2023-04-14T19:54:20ZengWileyAdvanced Science2198-38442023-04-011011n/an/a10.1002/advs.202207269Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force SensorsYuanqi Cheng0Juan Xu1Lan Li2Pingqiang Cai3Ying Li4Qing Jiang5Wei Wang6Yi Cao7Bin Xue8Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructure Department of Physics Nanjing University Nanjing 210093 P. R. ChinaKey Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital Affiliated to Medical School of Nanjing University Nanjing 210008 P. R. ChinaKey Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital Affiliated to Medical School of Nanjing University Nanjing 210008 P. R. ChinaKey Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital Affiliated to Medical School of Nanjing University Nanjing 210008 P. R. ChinaInstitute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Nanjing 210044 P. R. ChinaKey Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital Affiliated to Medical School of Nanjing University Nanjing 210008 P. R. ChinaCollaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructure Department of Physics Nanjing University Nanjing 210093 P. R. ChinaCollaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructure Department of Physics Nanjing University Nanjing 210093 P. R. ChinaCollaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State Microstructure Department of Physics Nanjing University Nanjing 210093 P. R. ChinaAbstract Biodegradable piezoelectric force sensors can be used as implantable medical devices for monitoring physiological pressures of impaired organs or providing essential stimuli for drug delivery and tissue regeneration without the need of additional invasive removal surgery or battery power. However, traditional piezoelectric materials, such as inorganic ceramics and organic polymers, show unsatisfactory degradability, and cytotoxicity. Amino acid crystals are biocompatible and exhibit outstanding piezoelectric properties, but their small crystal size makes it difficult to align the crystals for practical applications. Here, a mechanical‐annealing strategy is reported for engineering all‐organic biodegradable piezoelectric force sensors using natural amino acid crystals as piezoelectric materials. It is shown that the piezoelectric constant of the mechanical‐annealed crystals can reach 12 times that of the single crystal powders. Moreover, mechanical annealing results in flat and smooth surfaces, thus improving the contact of the crystal films with the electrodes and leading to high output voltages of the devices. The packaged force sensors can be used to monitor dynamic motions, including muscle contraction and lung respiration, in vivo for 4 weeks and then gradually degrade without causing obvious inflammation or systemic toxicity. This work provides a way to engineer all‐organic and biodegradable force sensors for potential clinical applications.https://doi.org/10.1002/advs.202207269biodegradableforce sensorspeptidespiezoelectricself‐assembly |
| spellingShingle | Yuanqi Cheng Juan Xu Lan Li Pingqiang Cai Ying Li Qing Jiang Wei Wang Yi Cao Bin Xue Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors Advanced Science biodegradable force sensors peptides piezoelectric self‐assembly |
| title | Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors |
| title_full | Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors |
| title_fullStr | Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors |
| title_full_unstemmed | Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors |
| title_short | Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors |
| title_sort | boosting the piezoelectric sensitivity of amino acid crystals by mechanical annealing for the engineering of fully degradable force sensors |
| topic | biodegradable force sensors peptides piezoelectric self‐assembly |
| url | https://doi.org/10.1002/advs.202207269 |
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