Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associate...

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Bibliographic Details
Main Authors: Diane Uschner, Matthew Bott, William H. Lagarde, Joseph Keating, Hazel Tapp, Andrea A. Berry, Austin L. Seals, Iqra Munawar, John Schieffelin, Joshua Yukich, Michele Santacatterina, Mihili Gunaratne, Lida M. Fette, Brian Burke, Greg Strylewicz, Sharon L. Edelstein, Amina Ahmed, Kristen Miller, John W. Sanders, David Herrington, William S. Weintraub, Michael S. Runyon, on behalf of the COVID-19 Community Research Partnership
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Vaccines
Subjects:
SARS-CoV-2 vaccination
cumulative incidence
booster vaccination
age
rural county
Omicron
Online Access:https://www.mdpi.com/2076-393X/10/11/1922
Description
Summary:We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.
ISSN:2076-393X

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