| Summary: | Background: The aim of the present study was to formulate and evaluate the herbal gels containing Chinese onion or Allium cepa (A. cepa), Yin Lian Ye or Azadirachta indica (A. indica) and Chinese peppermint or Menthe piperita (M. piperita) extracts and their antimicrobial effects against different microorganisms. All selected three plants have a good medicinal value in the Chinese medicine system. Methods: A topical gel formulation was designed by using mentioned plants, as well as all three in combination with Carbopol-940 as a gelling agent with different excipients. Microbial species, such as Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Aspergillus tubingensis (A. tubingensis) have been selected for the study and they are responsible for acne, directly or indirectly. Results: The gel's physical characteristics met the required benchmarks. These four gel formulations effectively inhibit the growth of selected strains. According to studies, the gel was also very efficient against fungal strains and gram-negative organisms. Zones of inhibition (ZOI) were found between 2.3 and 11.2 µm. The highest ZOI was measured against P. aeruginosa. Conclusion: The herbal gel was found to have highly promising anti-bacterial and anti-fungal activity against acne and many skin-related infections in a concentration-dependant manner but more research is needed.
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