Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China
Abstract Background Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant. Me...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12967-019-1794-6 |
| _version_ | 1811259595702665216 |
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| author | Donghui Yu Qinglong Deng Jiwei Wang Xing Chang Shuxiao Wang Renren Yang Jinming Yu Jing Yu |
| author_facet | Donghui Yu Qinglong Deng Jiwei Wang Xing Chang Shuxiao Wang Renren Yang Jinming Yu Jing Yu |
| author_sort | Donghui Yu |
| collection | DOAJ |
| description | Abstract Background Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant. Methods 23,922 eligible outpatients were recruited from ophthalmic clinics of 32 cities in China in 2013 by registration orders. The patients’ demographic characteristics, history of keratorefractive surgery, diseases and medication history were collected and the daily air pollutant data in 2013. Multivariate logistic analysis was performed to identify the potential risk factors associated with DED. The association between related factors and dry eye diseases subtypes evaluated as p value and odds ratios (OR) with 95% confidence intervals (CI). Results Among 23,922 outpatients, the prevalence of DED was 61.57%, and that of the male patients was 57.64% and of the female was 65.32% (P < 0.0001). Multivariate logistic regression suggested that the possible risk factors for DED included: female, older age, history of keratorefractive surgery, presence of arthritis, thyroid diseases, and antihistamine, diuretic, duodenal ulcer drugs, diazepam. Air pollutants including O3, PM2.5, and SO2 were also identified as the risk factors. Conclusion The prevalence of DED among ophthalmic outpatients in China was considerably high. Age, gender, history of keratorefractive surgery, diseases, medication history, and air pollutants were associated with DED prevalence. |
| first_indexed | 2024-04-12T18:34:02Z |
| format | Article |
| id | doaj.art-5f6a1b1f25fb4f59ada8632fba8ad51e |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-12T18:34:02Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-5f6a1b1f25fb4f59ada8632fba8ad51e2022-12-22T03:20:59ZengBMCJournal of Translational Medicine1479-58762019-02-011711910.1186/s12967-019-1794-6Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in ChinaDonghui Yu0Qinglong Deng1Jiwei Wang2Xing Chang3Shuxiao Wang4Renren Yang5Jinming Yu6Jing Yu7Department of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityInstitute of Clinical Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Ministry of Education, Fudan UniversityInstitute of Clinical Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Ministry of Education, Fudan UniversitySchool of Environment, Tsinghua UniversitySchool of Environment, Tsinghua UniversityInstitute of Clinical Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Ministry of Education, Fudan UniversityInstitute of Clinical Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Ministry of Education, Fudan UniversityDepartment of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityAbstract Background Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant. Methods 23,922 eligible outpatients were recruited from ophthalmic clinics of 32 cities in China in 2013 by registration orders. The patients’ demographic characteristics, history of keratorefractive surgery, diseases and medication history were collected and the daily air pollutant data in 2013. Multivariate logistic analysis was performed to identify the potential risk factors associated with DED. The association between related factors and dry eye diseases subtypes evaluated as p value and odds ratios (OR) with 95% confidence intervals (CI). Results Among 23,922 outpatients, the prevalence of DED was 61.57%, and that of the male patients was 57.64% and of the female was 65.32% (P < 0.0001). Multivariate logistic regression suggested that the possible risk factors for DED included: female, older age, history of keratorefractive surgery, presence of arthritis, thyroid diseases, and antihistamine, diuretic, duodenal ulcer drugs, diazepam. Air pollutants including O3, PM2.5, and SO2 were also identified as the risk factors. Conclusion The prevalence of DED among ophthalmic outpatients in China was considerably high. Age, gender, history of keratorefractive surgery, diseases, medication history, and air pollutants were associated with DED prevalence.http://link.springer.com/article/10.1186/s12967-019-1794-6Air pollutantChinaDry eye diseasePrevalence study |
| spellingShingle | Donghui Yu Qinglong Deng Jiwei Wang Xing Chang Shuxiao Wang Renren Yang Jinming Yu Jing Yu Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China Journal of Translational Medicine Air pollutant China Dry eye disease Prevalence study |
| title | Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China |
| title_full | Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China |
| title_fullStr | Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China |
| title_full_unstemmed | Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China |
| title_short | Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China |
| title_sort | air pollutants are associated with dry eye disease in urban ophthalmic outpatients a prevalence study in china |
| topic | Air pollutant China Dry eye disease Prevalence study |
| url | http://link.springer.com/article/10.1186/s12967-019-1794-6 |
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