Multi-platform-based characterization of ferroptosis in human colorectal cancer
Summary: Ferroptosis is a type of programmed cell death potentially playing an important role in colorectal cancer (CRC) development. However, comprehensive investigations toward ferroptosis in human CRC are lacking. Here, we performed multiple investigations on cancer and para-cancer tissues. We de...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222010227 |
| _version_ | 1818015698088099840 |
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| author | Yafang Zhong Wei Zhang Haiyan Yu Liewen Lin Xucan Gao Jingquan He Dandan Li Yumei Chen Zhipeng Zeng Yong Xu Donge Tang Yong Dai |
| author_facet | Yafang Zhong Wei Zhang Haiyan Yu Liewen Lin Xucan Gao Jingquan He Dandan Li Yumei Chen Zhipeng Zeng Yong Xu Donge Tang Yong Dai |
| author_sort | Yafang Zhong |
| collection | DOAJ |
| description | Summary: Ferroptosis is a type of programmed cell death potentially playing an important role in colorectal cancer (CRC) development. However, comprehensive investigations toward ferroptosis in human CRC are lacking. Here, we performed multiple investigations on cancer and para-cancer tissues. We demonstrated that the changes of structural variation and chromatin accessibility in CRC were more associated with the altered mRNA expression of ferroptosis-related genes (FRGs), and the expression of CDKN2A, GPX4, ALOXE3, and LINC00336 was related to the overall survival rates. Subsequently, we revealed that CYBB and YAP1 were potentially the hub genes, and that HSF1 and STAT2 were potentially FRGs’ upstream transcription factors. Finally, we depicted the crosstalk between ferroptosis and necrosis, autophagy, and apoptosis. Based on multi-dimensional analyses, we characterized ferroptosis, probable core genes, and the upstream regulators in human CRC. The findings here may improve our understanding of ferroptosis in CRC and provide new opportunities for clinical diagnosis and treatment. |
| first_indexed | 2024-04-14T07:01:22Z |
| format | Article |
| id | doaj.art-5f6af1fe4b3c40cbb481f640eebc5877 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-14T07:01:22Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-5f6af1fe4b3c40cbb481f640eebc58772022-12-22T02:06:44ZengElsevieriScience2589-00422022-08-01258104750Multi-platform-based characterization of ferroptosis in human colorectal cancerYafang Zhong0Wei Zhang1Haiyan Yu2Liewen Lin3Xucan Gao4Jingquan He5Dandan Li6Yumei Chen7Zhipeng Zeng8Yong Xu9Donge Tang10Yong Dai11Department of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaInnovative Markers Department, Guangdong Fapon Biopharma Inc, Dongguan 523808, China; Department of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, China; Innovative Markers Department, Guangdong Fapon Biotech Inc, Dongguan 523808, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, ChinaThe First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, ChinaDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, China; Corresponding authorDepartment of Clinical Medical Research Center, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, China; Corresponding authorSummary: Ferroptosis is a type of programmed cell death potentially playing an important role in colorectal cancer (CRC) development. However, comprehensive investigations toward ferroptosis in human CRC are lacking. Here, we performed multiple investigations on cancer and para-cancer tissues. We demonstrated that the changes of structural variation and chromatin accessibility in CRC were more associated with the altered mRNA expression of ferroptosis-related genes (FRGs), and the expression of CDKN2A, GPX4, ALOXE3, and LINC00336 was related to the overall survival rates. Subsequently, we revealed that CYBB and YAP1 were potentially the hub genes, and that HSF1 and STAT2 were potentially FRGs’ upstream transcription factors. Finally, we depicted the crosstalk between ferroptosis and necrosis, autophagy, and apoptosis. Based on multi-dimensional analyses, we characterized ferroptosis, probable core genes, and the upstream regulators in human CRC. The findings here may improve our understanding of ferroptosis in CRC and provide new opportunities for clinical diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S2589004222010227OncologyBiological sciencesBioinformaticsCancer |
| spellingShingle | Yafang Zhong Wei Zhang Haiyan Yu Liewen Lin Xucan Gao Jingquan He Dandan Li Yumei Chen Zhipeng Zeng Yong Xu Donge Tang Yong Dai Multi-platform-based characterization of ferroptosis in human colorectal cancer iScience Oncology Biological sciences Bioinformatics Cancer |
| title | Multi-platform-based characterization of ferroptosis in human colorectal cancer |
| title_full | Multi-platform-based characterization of ferroptosis in human colorectal cancer |
| title_fullStr | Multi-platform-based characterization of ferroptosis in human colorectal cancer |
| title_full_unstemmed | Multi-platform-based characterization of ferroptosis in human colorectal cancer |
| title_short | Multi-platform-based characterization of ferroptosis in human colorectal cancer |
| title_sort | multi platform based characterization of ferroptosis in human colorectal cancer |
| topic | Oncology Biological sciences Bioinformatics Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222010227 |
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