A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour
Prostate adenocarcinoma with testicular metastasis is rare, present in up to 4% of autopsy diagnoses, and presents symptomatically in less than 0.5% of cases. We report an unusual case of a 55-year-old male who developed a symptomatic testicular metastasis from primary prostate cancer 4 years after...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-11-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/525842 |
| _version_ | 1811290830520975360 |
|---|---|
| author | Jun Hee Hong Udit Nindra Rebecca Nguyen Paul Gassner Bavanthi Balakrishnar Tristan Rutland |
| author_facet | Jun Hee Hong Udit Nindra Rebecca Nguyen Paul Gassner Bavanthi Balakrishnar Tristan Rutland |
| author_sort | Jun Hee Hong |
| collection | DOAJ |
| description | Prostate adenocarcinoma with testicular metastasis is rare, present in up to 4% of autopsy diagnoses, and presents symptomatically in less than 0.5% of cases. We report an unusual case of a 55-year-old male who developed a symptomatic testicular metastasis from primary prostate cancer 4 years after initial diagnosis of metastatic castrate-sensitive prostate cancer with nodal and bone-only involvement. The patient had orchidectomy, histologically confirming the metastasis and revealing sparing of the spermatic cord. Prior treatment for his metastatic castrate-sensitive prostate cancer had included androgen deprivation therapy and upfront docetaxel chemotherapy. He had received palliative radiotherapy for symptomatic bone metastasis and managed on enzalutamide for castrate-resistant disease for the preceding 22 months with ongoing PSA response at the time of diagnosis of new testicular metastasis, with a further significant PSA response following his “testicular metastasectomy.” At the time of diagnosis of testicular metastasis, he did not have any evidence of other visceral metastases, and his metastatic disease otherwise remained radiologically stable. We describe his disease course, treatment and outline the rare nature of his case of testicular metastasis from prostate cancer. |
| first_indexed | 2024-04-13T04:20:22Z |
| format | Article |
| id | doaj.art-5f6b8132c4f64987a46344425d06f326 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T04:20:22Z |
| publishDate | 2022-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-5f6b8132c4f64987a46344425d06f3262022-12-22T03:02:48ZengKarger PublishersCase Reports in Oncology1662-65752022-11-011531055106210.1159/000525842525842A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular TumourJun Hee Hong0Udit Nindra1Rebecca Nguyen2https://orcid.org/0000-0001-8940-3161Paul Gassner3https://orcid.org/0000-0001-7196-5211Bavanthi Balakrishnar4Tristan Rutland5Department of Medical Oncology, Liverpool Hospital, Sydney, NSW, AustraliaDepartment of Medical Oncology, Liverpool Hospital, Sydney, NSW, AustraliaDepartment of Medical Oncology, Liverpool Hospital, Sydney, NSW, AustraliaDepartment of Urology, Liverpool Hospital, Sydney, NSW, AustraliaDepartment of Medical Oncology, Liverpool Hospital, Sydney, NSW, AustraliaDepartment of Anatomical Pathology, Liverpool Hospital, Sydney, NSW, AustraliaProstate adenocarcinoma with testicular metastasis is rare, present in up to 4% of autopsy diagnoses, and presents symptomatically in less than 0.5% of cases. We report an unusual case of a 55-year-old male who developed a symptomatic testicular metastasis from primary prostate cancer 4 years after initial diagnosis of metastatic castrate-sensitive prostate cancer with nodal and bone-only involvement. The patient had orchidectomy, histologically confirming the metastasis and revealing sparing of the spermatic cord. Prior treatment for his metastatic castrate-sensitive prostate cancer had included androgen deprivation therapy and upfront docetaxel chemotherapy. He had received palliative radiotherapy for symptomatic bone metastasis and managed on enzalutamide for castrate-resistant disease for the preceding 22 months with ongoing PSA response at the time of diagnosis of new testicular metastasis, with a further significant PSA response following his “testicular metastasectomy.” At the time of diagnosis of testicular metastasis, he did not have any evidence of other visceral metastases, and his metastatic disease otherwise remained radiologically stable. We describe his disease course, treatment and outline the rare nature of his case of testicular metastasis from prostate cancer.https://www.karger.com/Article/FullText/525842metastasectomymetastatic castrate-resistant prostate cancermetastatic prostate adenocarcinomatesticular metastasis |
| spellingShingle | Jun Hee Hong Udit Nindra Rebecca Nguyen Paul Gassner Bavanthi Balakrishnar Tristan Rutland A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour Case Reports in Oncology metastasectomy metastatic castrate-resistant prostate cancer metastatic prostate adenocarcinoma testicular metastasis |
| title | A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour |
| title_full | A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour |
| title_fullStr | A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour |
| title_full_unstemmed | A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour |
| title_short | A Rare Case of Castrate-Resistant Prostate Adenocarcinoma with a Unilateral Testicular Metastasis Mimicking a Primary Testicular Tumour |
| title_sort | rare case of castrate resistant prostate adenocarcinoma with a unilateral testicular metastasis mimicking a primary testicular tumour |
| topic | metastasectomy metastatic castrate-resistant prostate cancer metastatic prostate adenocarcinoma testicular metastasis |
| url | https://www.karger.com/Article/FullText/525842 |
| work_keys_str_mv | AT junheehong ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT uditnindra ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT rebeccanguyen ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT paulgassner ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT bavanthibalakrishnar ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT tristanrutland ararecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT junheehong rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT uditnindra rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT rebeccanguyen rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT paulgassner rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT bavanthibalakrishnar rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour AT tristanrutland rarecaseofcastrateresistantprostateadenocarcinomawithaunilateraltesticularmetastasismimickingaprimarytesticulartumour |