Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer
Films based on carrageenan, alginate and poloxamer 407 have been formulated with the main aim to apply prepared formulations in wound healing process. The formulated films were loaded with diclofenac, an anti-inflammatory drug, as well as diclofenac and curcumin, as multipurpose drug, in order to en...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/19/4091 |
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| author | Katarina S. Postolović Milan D. Antonijević Biljana Ljujić Slavko Radenković Marina Miletić Kovačević Zoltan Hiezl Svetlana Pavlović Ivana Radojević Zorka Stanić |
| author_facet | Katarina S. Postolović Milan D. Antonijević Biljana Ljujić Slavko Radenković Marina Miletić Kovačević Zoltan Hiezl Svetlana Pavlović Ivana Radojević Zorka Stanić |
| author_sort | Katarina S. Postolović |
| collection | DOAJ |
| description | Films based on carrageenan, alginate and poloxamer 407 have been formulated with the main aim to apply prepared formulations in wound healing process. The formulated films were loaded with diclofenac, an anti-inflammatory drug, as well as diclofenac and curcumin, as multipurpose drug, in order to enhance encapsulation and achieve controlled release of these low-bioavailability compounds. The obtained data demonstrated improved drug bioavailability (encapsulation efficiency higher than 90%), with high, cumulative in vitro release percentages (90.10% for diclofenac, 89.85% for curcumin and 95.61% for diclofenac in mixture-incorporated films). The results obtained using theoretical models suggested that curcumin establishes stronger, primarily dispersion interactions with carrier, in comparison with diclofenac. Curcumin and diclofenac-loaded films showed great antibacterial activity against Gram-positive bacteria strains (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>, inhibition zone 16.67 and 13.67 mm, respectively), and in vitro and in vivo studies indicated that curcumin- and diclofenac-incorporated polymer films have great potential, as a new transdermal dressing, to heal wounds, because diclofenac can target the inflammatory phase and reduce pain, whereas curcumin can enhance and promote the wound healing process. |
| first_indexed | 2024-03-09T21:15:52Z |
| format | Article |
| id | doaj.art-5f6bbe825a6f422a84f4c15830258506 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T21:15:52Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5f6bbe825a6f422a84f4c158302585062023-11-23T21:34:03ZengMDPI AGPolymers2073-43602022-09-011419409110.3390/polym14194091Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and PoloxamerKatarina S. Postolović0Milan D. Antonijević1Biljana Ljujić2Slavko Radenković3Marina Miletić Kovačević4Zoltan Hiezl5Svetlana Pavlović6Ivana Radojević7Zorka Stanić8Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaFaculty of Engineering and Science, School of Science, Medway Campus, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UKDepartment of Genetics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaFaculty of Engineering and Science, School of Science, Medway Campus, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UKFaculty of Engineering and Science, School of Science, Medway Campus, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UKDepartment of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, SerbiaFilms based on carrageenan, alginate and poloxamer 407 have been formulated with the main aim to apply prepared formulations in wound healing process. The formulated films were loaded with diclofenac, an anti-inflammatory drug, as well as diclofenac and curcumin, as multipurpose drug, in order to enhance encapsulation and achieve controlled release of these low-bioavailability compounds. The obtained data demonstrated improved drug bioavailability (encapsulation efficiency higher than 90%), with high, cumulative in vitro release percentages (90.10% for diclofenac, 89.85% for curcumin and 95.61% for diclofenac in mixture-incorporated films). The results obtained using theoretical models suggested that curcumin establishes stronger, primarily dispersion interactions with carrier, in comparison with diclofenac. Curcumin and diclofenac-loaded films showed great antibacterial activity against Gram-positive bacteria strains (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>, inhibition zone 16.67 and 13.67 mm, respectively), and in vitro and in vivo studies indicated that curcumin- and diclofenac-incorporated polymer films have great potential, as a new transdermal dressing, to heal wounds, because diclofenac can target the inflammatory phase and reduce pain, whereas curcumin can enhance and promote the wound healing process.https://www.mdpi.com/2073-4360/14/19/4091curcumindiclofenacfilmsbiopolymerscarrageenan/alginate/poloxamerwound healing |
| spellingShingle | Katarina S. Postolović Milan D. Antonijević Biljana Ljujić Slavko Radenković Marina Miletić Kovačević Zoltan Hiezl Svetlana Pavlović Ivana Radojević Zorka Stanić Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer Polymers curcumin diclofenac films biopolymers carrageenan/alginate/poloxamer wound healing |
| title | Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer |
| title_full | Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer |
| title_fullStr | Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer |
| title_full_unstemmed | Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer |
| title_short | Curcumin and Diclofenac Therapeutic Efficacy Enhancement Applying Transdermal Hydrogel Polymer Films, Based on Carrageenan, Alginate and Poloxamer |
| title_sort | curcumin and diclofenac therapeutic efficacy enhancement applying transdermal hydrogel polymer films based on carrageenan alginate and poloxamer |
| topic | curcumin diclofenac films biopolymers carrageenan/alginate/poloxamer wound healing |
| url | https://www.mdpi.com/2073-4360/14/19/4091 |
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