Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature
Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/2/332 |
| _version_ | 1827343070590402560 |
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| author | Siqi Liu Mengli Zhong Hao Wu Weiwei Su Yonggang Wang Peibo Li |
| author_facet | Siqi Liu Mengli Zhong Hao Wu Weiwei Su Yonggang Wang Peibo Li |
| author_sort | Siqi Liu |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection, known as long COVID. The effects of long COVID can be far-reaching, with a duration of up to six months and a range of symptoms such as cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive dysfunction, and thrombus formation. However, recent studies have shown that naringenin and naringin have palliative effects on various COVID-19 sequelae. Flavonoids such as naringin and naringenin, commonly found in fruits and vegetables, have various positive effects, including reducing inflammation, preventing viral infections, and providing antioxidants. This article discusses the molecular mechanisms and clinical effects of naringin and naringenin on treating the above diseases. It proposes them as potential drugs for the treatment of long COVID, and it can be inferred that naringin and naringenin exhibit potential as extended long COVID medications, in the future likely serving as nutraceuticals or clinical supplements for the comprehensive alleviation of the various manifestations of COVID-19 complications. |
| first_indexed | 2024-03-07T22:20:50Z |
| format | Article |
| id | doaj.art-5f6be43ee38b40bd9743b61752091e5b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-07T22:20:50Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5f6be43ee38b40bd9743b61752091e5b2024-02-23T15:28:14ZengMDPI AGMicroorganisms2076-26072024-02-0112233210.3390/microorganisms12020332Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the LiteratureSiqi Liu0Mengli Zhong1Hao Wu2Weiwei Su3Yonggang Wang4Peibo Li5Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaGuangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaGuangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaGuangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaGuangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaGuangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Market Traditional Chinese Medicine, State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, ChinaCoronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection, known as long COVID. The effects of long COVID can be far-reaching, with a duration of up to six months and a range of symptoms such as cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive dysfunction, and thrombus formation. However, recent studies have shown that naringenin and naringin have palliative effects on various COVID-19 sequelae. Flavonoids such as naringin and naringenin, commonly found in fruits and vegetables, have various positive effects, including reducing inflammation, preventing viral infections, and providing antioxidants. This article discusses the molecular mechanisms and clinical effects of naringin and naringenin on treating the above diseases. It proposes them as potential drugs for the treatment of long COVID, and it can be inferred that naringin and naringenin exhibit potential as extended long COVID medications, in the future likely serving as nutraceuticals or clinical supplements for the comprehensive alleviation of the various manifestations of COVID-19 complications.https://www.mdpi.com/2076-2607/12/2/332long COVIDSARS-CoV-2COVID-19naringinnaringeninbeneficial effects |
| spellingShingle | Siqi Liu Mengli Zhong Hao Wu Weiwei Su Yonggang Wang Peibo Li Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature Microorganisms long COVID SARS-CoV-2 COVID-19 naringin naringenin beneficial effects |
| title | Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature |
| title_full | Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature |
| title_fullStr | Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature |
| title_full_unstemmed | Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature |
| title_short | Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature |
| title_sort | potential beneficial effects of naringin and naringenin on long covid a review of the literature |
| topic | long COVID SARS-CoV-2 COVID-19 naringin naringenin beneficial effects |
| url | https://www.mdpi.com/2076-2607/12/2/332 |
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